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Depressive symptoms and clinical status during the Treatment of Adolescent Suicide Attempters (TASA) Study.

Publication ,  Journal Article
Vitiello, B; Brent, DA; Greenhill, LL; Emslie, G; Wells, K; Walkup, JT; Stanley, B; Bukstein, O; Kennard, BD; Compton, S; Coffey, B; Cwik, MF ...
Published in: J Am Acad Child Adolesc Psychiatry
October 2009

OBJECTIVE: To examine the course of depression during the treatment of adolescents with depression who had recently attempted suicide. METHOD: Adolescents (N = 124), ages 12 to 18 years, with a 90-day history of suicide attempt, a current diagnosis of depressive disorder (96.0% had major depressive disorder), and a Children's Depression Rating Scale-Revised (CDRS-R) score of 36 or higher, entered a 6-month treatment with antidepressant medication, cognitive-behavioral therapy focused on suicide prevention, or their combination (Comb), at five academic sites. Treatment assignment could be either random or chosen by study participants. Intent-to-treat, mixed effects regression models of depression and other relevant ratings were estimated. Improvement and remission rates were computed with the last observation carried forward. RESULTS: Most patients (n = 104 or 84%) chose treatment assignment, and overall, three fourths (n = 93) received Comb. In Comb, CDRS-R declined from a baseline adjusted mean of 49.6 (SD 12.3) to 38.3 (8.0) at week 12 and to 27.0 (10.1) at week 24 (p < .0001), with a Clinical Global Impression -defined improvement rate of 58.0% at week 12 and 72.2% at week 24 and a remission (CDRS-R ≤ 28) rate of 32.5% at week 12 and 50.0% at week 24. The CDRS-R and the Scale for Suicidal Ideation scores were correlated at baseline (r = 0.43, p < .0001) and declined in parallel. CONCLUSIONS: When vigorously treated with a combination of medication and psychotherapy, adolescents with depression who have recently attempted suicide show rates of improvement and remission of depression that seem comparable to those observed in nonsuicidal adolescents with depression.

Duke Scholars

Published In

J Am Acad Child Adolesc Psychiatry

DOI

EISSN

1527-5418

Publication Date

October 2009

Volume

48

Issue

10

Start / End Page

997 / 1004

Location

United States

Related Subject Headings

  • Suicide, Attempted
  • Secondary Prevention
  • Male
  • Interview, Psychological
  • Humans
  • Follow-Up Studies
  • Female
  • Dysthymic Disorder
  • Drug Therapy, Combination
  • Drug Resistance
 

Citation

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Vitiello, B., Brent, D. A., Greenhill, L. L., Emslie, G., Wells, K., Walkup, J. T., … Zelazny, J. (2009). Depressive symptoms and clinical status during the Treatment of Adolescent Suicide Attempters (TASA) Study. J Am Acad Child Adolesc Psychiatry, 48(10), 997–1004. https://doi.org/10.1097/CHI.0b013e3181b5db66
Vitiello, Benedetto, David A. Brent, Laurence L. Greenhill, Graham Emslie, Karen Wells, John T. Walkup, Barbara Stanley, et al. “Depressive symptoms and clinical status during the Treatment of Adolescent Suicide Attempters (TASA) Study.J Am Acad Child Adolesc Psychiatry 48, no. 10 (October 2009): 997–1004. https://doi.org/10.1097/CHI.0b013e3181b5db66.
Vitiello B, Brent DA, Greenhill LL, Emslie G, Wells K, Walkup JT, et al. Depressive symptoms and clinical status during the Treatment of Adolescent Suicide Attempters (TASA) Study. J Am Acad Child Adolesc Psychiatry. 2009 Oct;48(10):997–1004.
Vitiello, Benedetto, et al. “Depressive symptoms and clinical status during the Treatment of Adolescent Suicide Attempters (TASA) Study.J Am Acad Child Adolesc Psychiatry, vol. 48, no. 10, Oct. 2009, pp. 997–1004. Pubmed, doi:10.1097/CHI.0b013e3181b5db66.
Vitiello B, Brent DA, Greenhill LL, Emslie G, Wells K, Walkup JT, Stanley B, Bukstein O, Kennard BD, Compton S, Coffey B, Cwik MF, Posner K, Wagner A, March JS, Riddle M, Goldstein T, Curry J, Capasso L, Mayes T, Shen S, Gugga SS, Turner JB, Barnett S, Zelazny J. Depressive symptoms and clinical status during the Treatment of Adolescent Suicide Attempters (TASA) Study. J Am Acad Child Adolesc Psychiatry. 2009 Oct;48(10):997–1004.
Journal cover image

Published In

J Am Acad Child Adolesc Psychiatry

DOI

EISSN

1527-5418

Publication Date

October 2009

Volume

48

Issue

10

Start / End Page

997 / 1004

Location

United States

Related Subject Headings

  • Suicide, Attempted
  • Secondary Prevention
  • Male
  • Interview, Psychological
  • Humans
  • Follow-Up Studies
  • Female
  • Dysthymic Disorder
  • Drug Therapy, Combination
  • Drug Resistance