Empirically derived subtypes of adolescent depression: latent profile analysis of co-occurring symptoms in the Treatment for Adolescents with Depression Study (TADS).

Journal Article (Multicenter Study;Journal Article)

A latent profile analysis was conducted on the co-occurring symptoms of 423 adolescents diagnosed with major depressive disorder as part of the Treatment for Adolescents with Depression Study (TADS), a multisite, randomized treatment trial. The participants had a mean (SD) age of 14.6 (1.5) years; of the sample, 45.6% was male and 73.8% was white. Scores on the primary subscales of Conners' Parent Rating Scale--Revised were used as indicators in the analysis. Five classes of symptoms best described the clinical presentation of adolescents enrolled in the TADS. Of the adolescents in the sample, 80% were assigned to classes with clinically significant elevations on 1 or more subscales of the Children's Depression Rating Scale--Revised. The 5 classes met empirical criteria for distinctiveness and were validated against clinical diagnoses, child-rated symptoms, and clinician-rated functional impairment. The findings are consistent with prior studies that showed a high rate of co-occurring symptoms among depressed adolescents. The discussion focuses on understanding subtypes and comorbidity in adolescent depression as well as the implications for treatment and for prevention.

Full Text

Duke Authors

Cited Authors

  • Herman, KC; Ostrander, R; Walkup, JT; Silva, SG; March, JS

Published Date

  • October 2007

Published In

Volume / Issue

  • 75 / 5

Start / End Page

  • 716 - 728

PubMed ID

  • 17907854

Electronic International Standard Serial Number (EISSN)

  • 1939-2117

International Standard Serial Number (ISSN)

  • 0022-006X

Digital Object Identifier (DOI)

  • 10.1037/0022-006x.75.5.716


  • eng