A manual-based intervention to address clinical crises and retain patients in the Treatment of Adolescents With Depression Study (TADS).

Journal Article (Clinical Trial;Journal Article)

Objective

To describe a manual-based intervention to address clinical crises and retain participants in the Treatment for Adolescents With Depression Study (TADS).

Method

The use of adjunct services for attrition prevention (ASAP) is described for adolescents (ages 12-17 years) during the 12-week acute treatment in TADS, from 2000 to 2003. Logistic regression, controlling for site, was used to predict use.

Results

Of 439 enrolled participants, 17.8% (n = 78) used ASAP primarily for suicidality or worsening of depression. Of these, 46.2% continued in their assigned treatment through week 12, 47.4% received out-of-protocol treatment but continued participating in assessments, and 10.3% withdrew consent, including 3 who terminated treatment and withdrew consent on the same date. ASAP use did not differ between treatments (p =.97) and typically occurred early in treatment. At the end of the 12 weeks, 37.2% of participants using ASAP remained in their assigned treatment, although 80.8% continued participating in assessments. ASAP was associated with, at baseline, a higher severity of depression (p <.01), substance use (p <.01), and precontemplation level of change (p <.02).

Conclusions

ASAP may be useful to retain adolescent participants and as a safety intervention in placebo-controlled trials. In clinical practice ASAP-like procedures may be useful to encourage adherence in patients engaging in long-term treatment. Clinical trial registration information-URL: http://www.clinicaltrials.gov. Unique identifier: NCT00006286.

Full Text

Duke Authors

Cited Authors

  • May, DE; Kratochvil, CJ; Puumala, SE; Silva, SG; Rezac, AJ; Hallin, MJ; Reinecke, MA; Vitiello, B; Weller, EB; Pathak, S; Simons, AD; March, JS

Published Date

  • May 2007

Published In

Volume / Issue

  • 46 / 5

Start / End Page

  • 573 - 581

PubMed ID

  • 17450048

Electronic International Standard Serial Number (EISSN)

  • 1527-5418

International Standard Serial Number (ISSN)

  • 0890-8567

Digital Object Identifier (DOI)

  • 10.1097/chi.0b013e3180323342

Language

  • eng