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Cigarette smoking is associated with advanced renal cell carcinoma.

Publication ,  Journal Article
Tsivian, M; Moreira, DM; Caso, JR; Mouraviev, V; Polascik, TJ
Published in: J Clin Oncol
May 20, 2011

PURPOSE: Cigarette smoking is a recognized risk factor for renal cell carcinoma (RCC), but little data are available on the association between smoking and RCC biology. We investigated the association between cigarette smoking and RCC stage in a large contemporary multiethnic surgical cohort. PATIENTS AND METHODS: We retrospectively reviewed the demographic, clinical, and pathologic data of patients undergoing surgery for RCC between 2000 and 2009. Advanced RCC was defined as metastatic disease, pathologic stage ≥ T3, and/or lymph node involvement. Self-reported smoking history included smoking status, duration, intensity, cumulative exposure, and cessation. Patient and tumor characteristics were compared between the groups in univariate and multivariate analyses. RESULTS: Of the 845 eligible patients, 19.4% and 29.1% were current and former smokers, respectively, and 207 patients (24.5%) had advanced disease. In both univariate and multivariate analyses, smoking was consistently associated with advanced RCC, and cessation reversed the risk. Current and former smokers had 1.5- and 1.6-fold increased odds of advanced disease, respectively. Heavier smoking (longer duration and exposure) was associated with increased risk of advanced RCC, whereas durable cessation reduced the odds of advanced disease. CONCLUSION: Cigarette smoking is an independent risk factor for advanced RCC. Heavier smoking increases the likelihood of advanced disease. Durable smoking cessation attenuated the risk of advanced disease. Given that cigarette smoking is among the few modifiable risk factors for RCC, our results reinforce the importance of smoking cessation and encourage further investigation of the association between smoking and RCC biology.

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Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

May 20, 2011

Volume

29

Issue

15

Start / End Page

2027 / 2031

Location

United States

Related Subject Headings

  • Time Factors
  • Smoking Cessation
  • Smoking
  • Risk Factors
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Kidney Neoplasms
  • Humans
  • Female
 

Citation

APA
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ICMJE
MLA
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Tsivian, M., Moreira, D. M., Caso, J. R., Mouraviev, V., & Polascik, T. J. (2011). Cigarette smoking is associated with advanced renal cell carcinoma. J Clin Oncol, 29(15), 2027–2031. https://doi.org/10.1200/JCO.2010.30.9484
Tsivian, Matvey, Daniel M. Moreira, Jorge R. Caso, Vladimir Mouraviev, and Thomas J. Polascik. “Cigarette smoking is associated with advanced renal cell carcinoma.J Clin Oncol 29, no. 15 (May 20, 2011): 2027–31. https://doi.org/10.1200/JCO.2010.30.9484.
Tsivian M, Moreira DM, Caso JR, Mouraviev V, Polascik TJ. Cigarette smoking is associated with advanced renal cell carcinoma. J Clin Oncol. 2011 May 20;29(15):2027–31.
Tsivian, Matvey, et al. “Cigarette smoking is associated with advanced renal cell carcinoma.J Clin Oncol, vol. 29, no. 15, May 2011, pp. 2027–31. Pubmed, doi:10.1200/JCO.2010.30.9484.
Tsivian M, Moreira DM, Caso JR, Mouraviev V, Polascik TJ. Cigarette smoking is associated with advanced renal cell carcinoma. J Clin Oncol. 2011 May 20;29(15):2027–2031.

Published In

J Clin Oncol

DOI

EISSN

1527-7755

Publication Date

May 20, 2011

Volume

29

Issue

15

Start / End Page

2027 / 2031

Location

United States

Related Subject Headings

  • Time Factors
  • Smoking Cessation
  • Smoking
  • Risk Factors
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Kidney Neoplasms
  • Humans
  • Female