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Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer.

Publication ,  Journal Article
Heymach, JV; Shackleford, TJ; Tran, HT; Yoo, S-Y; Do, K-A; Wergin, M; Saintigny, P; Vollmer, RT; Polascik, TJ; Snyder, DC; Ruffin, MT; Yan, S ...
Published in: Cancer Prev Res (Phila)
October 2011

Diet, nutritional status, and certain dietary supplements are postulated to influence the development and progression of prostate cancer. Angiogenesis and inflammation are central to tumor growth and progression, but the effect of diet on these processes remains uncertain. We explored changes in 50 plasma cytokines and angiogenic factors (CAF) in 145 men with prostate cancer enrolled in a preoperative, randomized controlled phase II trial with four arms: control (usual diet), low-fat (LF) diet, flaxseed-supplemented (FS) diet, and FS+LS diet. The mean duration of dietary intervention was 30 to 31 days. Among the individual arms, the largest number of significant changes (baseline vs. preoperative follow-up) was observed in the LF arm, with 19 CAFs decreasing and one increasing (P < 0.05). Compared with the control arm, 6 CAFs-including proangiogenic factors (stromal-cell derived-1α) and myeloid factors (granulocyte-colony-stimulating factor, macrophage colony-stimulating factor)-all decreased in the LF arm compared with controls; three and four CAFs changed in the FS and FS+LF arms, respectively. Weight loss occurred in the LF arms and significantly correlated with VEGF decreases (P < 0.001). The CAFs that changed in the LF arm are all known to be regulated by NF-κB, and a pathway analysis identified NF-κB as the most likely regulatory network associated with these changes in the LF arm but not in the FS-containing arms. These results suggest that a LF diet without flaxseed may reduce levels of specific inflammatory CAFs and suggests that the NF-κB pathway may be a mediator of these changes.

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Published In

Cancer Prev Res (Phila)

DOI

EISSN

1940-6215

Publication Date

October 2011

Volume

4

Issue

10

Start / End Page

1590 / 1598

Location

United States

Related Subject Headings

  • Weight Loss
  • Prostatic Neoplasms
  • Prognosis
  • Oncology & Carcinogenesis
  • NF-kappa B
  • Male
  • Inflammation Mediators
  • Immunoenzyme Techniques
  • Humans
  • Follow-Up Studies
 

Citation

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Heymach, J. V., Shackleford, T. J., Tran, H. T., Yoo, S.-Y., Do, K.-A., Wergin, M., … Demark-Wahnefried, W. (2011). Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer. Cancer Prev Res (Phila), 4(10), 1590–1598. https://doi.org/10.1158/1940-6207.CAPR-10-0136
Heymach, John V., Terry J. Shackleford, Hai T. Tran, Suk-Young Yoo, Kim-Anh Do, Melanie Wergin, Pierre Saintigny, et al. “Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer.Cancer Prev Res (Phila) 4, no. 10 (October 2011): 1590–98. https://doi.org/10.1158/1940-6207.CAPR-10-0136.
Heymach JV, Shackleford TJ, Tran HT, Yoo S-Y, Do K-A, Wergin M, et al. Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer. Cancer Prev Res (Phila). 2011 Oct;4(10):1590–8.
Heymach, John V., et al. “Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer.Cancer Prev Res (Phila), vol. 4, no. 10, Oct. 2011, pp. 1590–98. Pubmed, doi:10.1158/1940-6207.CAPR-10-0136.
Heymach JV, Shackleford TJ, Tran HT, Yoo S-Y, Do K-A, Wergin M, Saintigny P, Vollmer RT, Polascik TJ, Snyder DC, Ruffin MT, Yan S, Dewhirst M, Kunnumakkara AB, Aggarwal BB, Demark-Wahnefried W. Effect of low-fat diets on plasma levels of NF-κB-regulated inflammatory cytokines and angiogenic factors in men with prostate cancer. Cancer Prev Res (Phila). 2011 Oct;4(10):1590–1598.

Published In

Cancer Prev Res (Phila)

DOI

EISSN

1940-6215

Publication Date

October 2011

Volume

4

Issue

10

Start / End Page

1590 / 1598

Location

United States

Related Subject Headings

  • Weight Loss
  • Prostatic Neoplasms
  • Prognosis
  • Oncology & Carcinogenesis
  • NF-kappa B
  • Male
  • Inflammation Mediators
  • Immunoenzyme Techniques
  • Humans
  • Follow-Up Studies