Tissue engineering in the cardiovascular system: progress toward a tissue engineered heart.

Journal Article (Review;Journal Article)

Achieving the lofty goal of developing a tissue engineered heart will likely rely on progress in engineering the various components: blood vessels, heart valves, and cardiac muscle. Advances in tissue engineered vascular grafts have shown the most progress to date. Research in tissue-engineered vascular grafts has focused on improving scaffold design, including mechanical properties and bioactivity; genetically engineering cells to improve graft performance; and optimizing tissue formation through in vitro mechanical conditioning. Some of these same approaches have been used in developing tissue engineering heart valves and cardiac muscle as well. Continued advances in scaffold technology and a greater understanding of vascular cell biology along with collaboration among engineers, scientists, and physicians will lead to further progress in the field of cardiovascular tissue engineering and ultimately the development of a tissue-engineered heart.

Full Text

Duke Authors

Cited Authors

  • Mann, BK; West, JL

Published Date

  • August 2001

Published In

Volume / Issue

  • 263 / 4

Start / End Page

  • 367 - 371

PubMed ID

  • 11500813

Electronic International Standard Serial Number (EISSN)

  • 1097-0185

International Standard Serial Number (ISSN)

  • 0003-276X

Digital Object Identifier (DOI)

  • 10.1002/ar.1116


  • eng