EphrinA I-targeted nanoshells for photothermal ablation of prostate cancer cells.


Journal Article

Gold-coated silica nanoshells are a class of nanoparticles that can be designed to possess strong absorption of light in the near infrared (NIR) wavelength region. When injected intravenously, these nanoshells have been shown to accumulate in tumors and subsequently mediate photothermal treatment, leading to tumor regression. In this work, we sought to improve their specificity by targeting them to prostate tumor cells. We report selective targeting of PC-3 cells with nanoshells conjugated to ephrinA I, a ligand for EphA2 receptor that is overexpressed on PC-3 cells. We demonstrate selective photo-thermal destruction of these cells upon application of the NIR laser.

Full Text

Duke Authors

Cited Authors

  • Gobin, AM; Moon, JJ; West, JL

Published Date

  • January 2008

Published In

Volume / Issue

  • 3 / 3

Start / End Page

  • 351 - 358

PubMed ID

  • 18990944

Pubmed Central ID

  • 18990944

Electronic International Standard Serial Number (EISSN)

  • 1178-2013

International Standard Serial Number (ISSN)

  • 1176-9114


  • eng