Near-infrared resonant nanoshells for combined optical imaging and photothermal cancer therapy.

Journal Article (Journal Article)

Metal nanoshells are core/shell nanoparticles that can be designed to either strongly absorb or scatter within the near-infrared (NIR) wavelength region ( approximately 650-950 nm). Nanoshells were designed that possess both absorption and scattering properties in the NIR to provide optical contrast for improved diagnostic imaging and, at higher light intensity, rapid heating for photothermal therapy. Using these in a mouse model, we have demonstrated dramatic contrast enhancement for optical coherence tomography (OCT) and effective photothermal ablation of tumors.

Full Text

Duke Authors

Cited Authors

  • Gobin, AM; Lee, MH; Halas, NJ; James, WD; Drezek, RA; West, JL

Published Date

  • July 2007

Published In

Volume / Issue

  • 7 / 7

Start / End Page

  • 1929 - 1934

PubMed ID

  • 17550297

Electronic International Standard Serial Number (EISSN)

  • 1530-6992

International Standard Serial Number (ISSN)

  • 1530-6984

Digital Object Identifier (DOI)

  • 10.1021/nl070610y


  • eng