Antibody-conjugated gold-gold sulfide nanoparticles as multifunctional agents for imaging and therapy of breast cancer.

Published

Journal Article

The goal of this study was to develop near-infrared (NIR) resonant gold-gold sulfide nanoparticles (GGS-NPs) as dual contrast and therapeutic agents for cancer management via multiphoton microscopy followed by higher intensity photoablation. We demonstrate that GGS-NPs exposed to a pulsed, NIR laser exhibit two-photon induced photoluminescence that can be utilized to visualize cancerous cells in vitro. When conjugated with anti-HER2 antibodies, these nanoparticles specifically bind SK-BR-3 breast carcinoma cells that over-express the HER2 receptor, enabling the cells to be imaged via multiphoton microscopy with an incident laser power of 1 mW. Higher excitation power (50 mW) could be employed to induce thermal damage to the cancerous cells, producing extensive membrane blebbing within seconds leading to cell death. GGS-NPs are ideal multifunctional agents for cancer management because they offer the ability to pinpoint precise treatment sites and perform subsequent thermal ablation in a single setting.

Full Text

Duke Authors

Cited Authors

  • Day, ES; Bickford, LR; Slater, JH; Riggall, NS; Drezek, RA; West, JL

Published Date

  • January 2010

Published In

Volume / Issue

  • 5 /

Start / End Page

  • 445 - 454

PubMed ID

  • 20957166

Pubmed Central ID

  • 20957166

Electronic International Standard Serial Number (EISSN)

  • 1178-2013

International Standard Serial Number (ISSN)

  • 1176-9114

Digital Object Identifier (DOI)

  • 10.2147/ijn.s10881

Language

  • eng