Nitric oxide-releasing polyurethane-PEG copolymer containing the YIGSR peptide promotes endothelialization with decreased platelet adhesion.

Published

Journal Article

Thrombosis and intimal hyperplasia are the principal causes of small-diameter vascular graft failure. To improve the long-term patency of polyurethane vascular grafts, we have incorporated both poly(ethylene glycol) and a diazeniumdiolate nitric oxide (NO) donor into the backbone of polyurethane to improve thromboresistance. Additionally, we have incorporated the laminin-derived cell adhesive peptide sequence YIGSR to encourage endothelial cell adhesion and migration, while NO release encourages endothelial cell proliferation. NO production by polyurethane films under physiological conditions demonstrated biphasic release, in which an initial burst of 70% of the incorporated NO was released within 2 days, followed by sustained release over 2 months. Endothelial cell proliferation in the presence of the NO-releasing material was increased as compared to control polyurethane, and platelet adhesion to polyethylene glycol-containing polyurethane was decreased significantly with the addition of the NO donor.

Full Text

Duke Authors

Cited Authors

  • Taite, LJ; Yang, P; Jun, H-W; West, JL

Published Date

  • January 2008

Published In

Volume / Issue

  • 84 / 1

Start / End Page

  • 108 - 116

PubMed ID

  • 17497680

Pubmed Central ID

  • 17497680

Electronic International Standard Serial Number (EISSN)

  • 1552-4981

International Standard Serial Number (ISSN)

  • 1552-4973

Digital Object Identifier (DOI)

  • 10.1002/jbm.b.30850

Language

  • eng