Modification of polyurethaneurea with PEG and YIGSR peptide to enhance endothelialization without platelet adhesion.

Published

Journal Article

Improved endothelialization without platelet adhesion is essential to enhance the long-term patency of synthetic vascular grafts and other blood-contacting devices. We have developed a dually modified polyurethaneurea by incorporating endothelial cell adhesive YIGSR peptide sequences as chain extenders and nonthrombogenic PEG as a soft segment (PUUYIGSR-PEG) in the polymer backbone. PUUYIGSR-PEG was successfully synthesized and characterized by proton NMR, FTIR, GPC, DSC, ESCA, and contact angle measurement. Despite having similar molecular weight, the peptide/PEG-modified polyurethaneurea (PUUYIGSR-PEG) showed superior mechanical properties compared to the control PEG-modified polyurethaneurea (PUUPPD-PEG). Virtually no platelet adhesion was observed on PUUYIGSR-PEG, while endothelial cell adhesion, spreading, and migration were significantly greater on PUUYIGSR-PEG compared to PUUPPD-PEG. Thus, this bioactive polymer may be an appropriate biomaterial for small diameter vascular grafts.

Full Text

Duke Authors

Cited Authors

  • Jun, H-W; West, JL

Published Date

  • January 2005

Published In

Volume / Issue

  • 72 / 1

Start / End Page

  • 131 - 139

PubMed ID

  • 15389489

Pubmed Central ID

  • 15389489

Electronic International Standard Serial Number (EISSN)

  • 1552-4981

International Standard Serial Number (ISSN)

  • 1552-4973

Digital Object Identifier (DOI)

  • 10.1002/jbm.b.30135

Language

  • eng