Biomimetic hydrogels with pro-angiogenic properties.

Published

Journal Article

To achieve the task of fabricating functional tissues, scaffold materials that can be sufficiently vascularized to mimic functionality and complexity of native tissues are yet to be developed. Here, we report development of synthetic, biomimetic hydrogels that allow the rapid formation of a stable and mature vascular network both in vitro and in vivo. Hydrogels were fabricated with integrin binding sites and protease-sensitive substrates to mimic the natural provisional extracellular matrices, and endothelial cells cultured in these hydrogels organized into stable, intricate networks of capillary-like structures. The resulting structures were further stabilized by recruitment of mesenchymal progenitor cells that differentiated into a smooth muscle cell lineage and deposited collagen IV and laminin in vitro. In addition, hydrogels transplanted into mouse corneas were infiltrated with host vasculature, resulting in extensive vascularization with functional blood vessels. These results indicate that these hydrogels may be useful for applications in basic biological research, tissue engineering, and regenerative medicine.

Full Text

Duke Authors

Cited Authors

  • Moon, JJ; Saik, JE; Poché, RA; Leslie-Barbick, JE; Lee, S-H; Smith, AA; Dickinson, ME; West, JL

Published Date

  • May 2010

Published In

Volume / Issue

  • 31 / 14

Start / End Page

  • 3840 - 3847

PubMed ID

  • 20185173

Pubmed Central ID

  • 20185173

Electronic International Standard Serial Number (EISSN)

  • 1878-5905

International Standard Serial Number (ISSN)

  • 0142-9612

Digital Object Identifier (DOI)

  • 10.1016/j.biomaterials.2010.01.104

Language

  • eng