Vascularization of engineered tissues: approaches to promote angio-genesis in biomaterials.

Journal Article (Review;Journal Article)

Although there have been extensive research efforts to create functional tissues and organs, most successes in tissue engineering have been limited to avascular or thin tissues. The major hurdle in development of more complex tissues lies in the formation of vascular networks capable of delivering oxygen and nutrients throughout the engineered constructs. Sufficient neovascularization in scaffold materials can be achieved through coordinated application of angiogenic factors with proper cell types in biomaterials. This review present the current research developments in the design of biomaterials and their biochemical and biochemical modifications to produce vascularized tissue constructs.

Full Text

Duke Authors

Cited Authors

  • Moon, JJ; West, JL

Published Date

  • January 2008

Published In

Volume / Issue

  • 8 / 4

Start / End Page

  • 300 - 310

PubMed ID

  • 18393893

Pubmed Central ID

  • PMC3929210

Electronic International Standard Serial Number (EISSN)

  • 1873-4294

International Standard Serial Number (ISSN)

  • 1568-0266

Digital Object Identifier (DOI)

  • 10.2174/156802608783790983


  • eng