Nitric oxide-generating hydrogels inhibit neointima formation.
Journal Article (Journal Article)
This study evaluated the effects of localized delivery of nitric oxide (NO) from hydrogels covalently modified with S-nitrosocysteine (Cys-NO) on neoinitma formation, a key component of restenosis, in a rat balloon-injury model. Soluble Cys-NO was used in preliminary studies to identify dosage ranges that were able to simultaneously inhibit smooth muscle cell proliferation, enhance endothelial cell proliferation, and reduce platelet adhesion. Photo-cross-linked PEG-based hydrogels were formed with covalently immobilized Cys-NO. These materials release NO for approximately 24 h and can be applied to tissues and photo-cross-linked in situ to form local drug-delivery systems. Localized delivery of NO from hydrogels containing Cys-NO inhibited neointima formation in a rat balloon-injury model by approximately 75% at 14 days.
Full Text
Duke Authors
Cited Authors
- Masters, KSB; Lipke, EA; Rice, EEH; Liel, MS; Myler, HA; Zygourakis, C; Tulis, DA; West, JL
Published Date
- January 2005
Published In
Volume / Issue
- 16 / 5
Start / End Page
- 659 - 672
PubMed ID
- 16001723
Electronic International Standard Serial Number (EISSN)
- 1568-5624
International Standard Serial Number (ISSN)
- 0920-5063
Digital Object Identifier (DOI)
- 10.1163/1568562053783722
Language
- eng