Nitric oxide-generating hydrogels inhibit neointima formation.

Journal Article (Journal Article)

This study evaluated the effects of localized delivery of nitric oxide (NO) from hydrogels covalently modified with S-nitrosocysteine (Cys-NO) on neoinitma formation, a key component of restenosis, in a rat balloon-injury model. Soluble Cys-NO was used in preliminary studies to identify dosage ranges that were able to simultaneously inhibit smooth muscle cell proliferation, enhance endothelial cell proliferation, and reduce platelet adhesion. Photo-cross-linked PEG-based hydrogels were formed with covalently immobilized Cys-NO. These materials release NO for approximately 24 h and can be applied to tissues and photo-cross-linked in situ to form local drug-delivery systems. Localized delivery of NO from hydrogels containing Cys-NO inhibited neointima formation in a rat balloon-injury model by approximately 75% at 14 days.

Full Text

Duke Authors

Cited Authors

  • Masters, KSB; Lipke, EA; Rice, EEH; Liel, MS; Myler, HA; Zygourakis, C; Tulis, DA; West, JL

Published Date

  • January 2005

Published In

Volume / Issue

  • 16 / 5

Start / End Page

  • 659 - 672

PubMed ID

  • 16001723

Electronic International Standard Serial Number (EISSN)

  • 1568-5624

International Standard Serial Number (ISSN)

  • 0920-5063

Digital Object Identifier (DOI)

  • 10.1163/1568562053783722


  • eng