The Flk1-myr::mCherry mouse as a useful reporter to characterize multiple aspects of ocular blood vessel development and disease.

Journal Article (Journal Article)

The highly vascularized mouse eye is an excellent model system in which to elucidate the molecular genetic basis of blood vessel development and disease. However, the analysis of ocular vessel defects has traditionally been derived from fixed tissue, which fails to account for dynamic events such as blood flow and cell migration. To overcome the limitations of static analysis, tremendous advances in imaging technology and fluorescent protein reporter mouse lines now enable the direct visualization of developing cells in vivo. Here, we demonstrate that the Flk1-myr::mCherry transgenic mouse is an extremely useful live reporter with broad applicability to retinal, hyaloid, and choroid vascular research.

Full Text

Duke Authors

Cited Authors

  • Poché, RA; Larina, IV; Scott, ML; Saik, JE; West, JL; Dickinson, ME

Published Date

  • September 2009

Published In

Volume / Issue

  • 238 / 9

Start / End Page

  • 2318 - 2326

PubMed ID

  • 19253403

Pubmed Central ID

  • PMC2901875

Electronic International Standard Serial Number (EISSN)

  • 1097-0177

International Standard Serial Number (ISSN)

  • 1058-8388

Digital Object Identifier (DOI)

  • 10.1002/dvdy.21886


  • eng