Three-dimensional biochemical and biomechanical patterning of hydrogels for guiding cell behavior

A new model for the fabrication of internally complex materials through controlled 3D biochemical and biomechanical patterning of hydrogels and guiding cell behavior within existing photoactive scaffolds is presented. It has been approved using single-photon absorption (SPA) and two-photon absorption (TPA) photolithography to internally immobilize mono- and diacrylate-derivatized moieties into performed poly(ethylene glycol) (PEG)-diacrylate (PEGDA) hydrogels. The pattering can potentially be extended to the creation of complex 3D structures on surfaces rather than within existing networks. The generated internally complex materials through the model can be used to guide cell migration can be used to guide cell migration and represents a significant approach for the exploration of biotechnology.

Full Text

Duke Authors

Cited Authors

  • Hahn, MS; Miller, JS; West, JL

Published Date

  • 2006

Published In

Volume / Issue

  • 18 / 20

Start / End Page

  • 2679 - 2684

International Standard Serial Number (ISSN)

  • 0935-9648

Digital Object Identifier (DOI)

  • 10.1002/adma.200600647

Citation Source

  • SciVal