Risk factors for infective endocarditis in patients with enterococcal bacteremia: a case-control study.

Journal Article

BACKGROUND: Based on previous studies, enterococcal infective endocarditis (IE) is considered a unimicrobial, community-acquired disease of older Caucasian men. PATIENTS AND METHODS: We evaluated the relationship between enterococcal bacteremia and IE by comparing clinical and demographic characteristics of all cases of enterococcal IE within an 8-year period (n = 41) with controls randomly chosen from patients with enterococcal bacteremia without IE. RESULTS: By univariate and multivariable analyses, the presence of a prosthetic valve (PV) and infection with Enterococcus faecalis were significantly associated with IE, while age, gender, race, polymicrobial infection and community-acquired infection were not. Almost an equal number of women and men had enterococcal IE. Cases of enterococcal IE were commonly nosocomial (39%) and polymicrobial (17%). CONCLUSIONS: Enterococcal endocarditis can no longer be considered exclusively a unimicrobial, community-acquired disease of Caucasian men. Instead, our data suggest that the presence of a PV and infection by E. faecalis are associated with an increased risk for IE.

Full Text

Duke Authors

Cited Authors

  • Anderson, DJ; Murdoch, DR; Sexton, DJ; Reller, LB; Stout, JE; Cabell, CH; Corey, GR

Published Date

  • April 2004

Published In

Volume / Issue

  • 32 / 2

Start / End Page

  • 72 - 77

PubMed ID

  • 15057570

International Standard Serial Number (ISSN)

  • 0300-8126

Digital Object Identifier (DOI)

  • 10.1007/s15010-004-2036-1


  • eng

Conference Location

  • Germany