Inappropriate antidiuretic hormone secretion. Occurrence in a patient with Rocky Mountain spotted fever.

Journal Article

A 51-year-old man with serologically confirmed Rocky Mountain spotted fever was believed to have inappropriate antidiuretic hormone (ADH) secretion. He was observed for four days in the hospital until the correct diagnosis was made. During this period, he progressively became more hyponatremic, despite a low BUN level and the administration of large amounts of sodium and water. At the time, his serum sodium concentration was 117 mEq/liter, and his urine was hypertonic to that of serum. Thereafter, his serum sodium level rose with fluid restriction. Rickettsia-induced CNS damage may have lead to the inappropriate ADH release that was observed in this patient.

Full Text

Duke Authors

Cited Authors

  • Sexton, DJ; Clapp, J

Published Date

  • March 1, 1977

Published In

Volume / Issue

  • 137 / 3

Start / End Page

  • 362 - 363

PubMed ID

  • 843153

Pubmed Central ID

  • 843153

International Standard Serial Number (ISSN)

  • 0003-9926

Digital Object Identifier (DOI)

  • 10.1001/archinte.137.3.362


  • eng

Conference Location

  • United States