Influence of diabetes mellitus on the clinical manifestations and prognosis of infective endocarditis: a report from the International Collaboration on Endocarditis-Merged Database.

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The purpose of this investigation was to study the influence of diabetes mellitus (DM) on outcomes of infective endocarditis (IE). Outcomes were compared between 150 diabetic and 905 non-diabetic patients with IE from the International Collaboration on Endocarditis Merged Database. Compared to non-diabetic patients, diabetic patients were older (median age 63 vs 57 y, p<0.001), were more often female (42.0% vs 31.9%, p=0.01), more often had comorbidities (41.5% vs 26.7%, p<0.001), and were more likely to be dialysis dependent (12.7% vs 4.0%, p<0.001). S. aureus was isolated more often (30.7% vs 21.7%, p=0.02), and microorganisms from the viridans Streptococcus group less often (16.7% vs 28.2%, p = 0.001) in the diabetic group. There was no difference with respect to the presence of congestive heart failure, embolism, intra-cardiac abscess, new valvular regurgitation, or valvular vegetation. Diabetic patients underwent surgical intervention less frequently (32.0% vs 44.9%, p = 0.003), and had higher overall in-hospital mortality (30.3% vs 18.6%, p = 0.001). On multivariable analysis, DM was an independent predictor of mortality (odds ratio (OR) = 1.71, 95% confidence interval (CI) 1.08-2.70), especially in male patients, as diabetic males had higher mortality than non-diabetic males (OR 2.18, CI 1.08-4.35). DM is an independent predictor of in-hospital mortality among patients hospitalized with IE.

Full Text

Duke Authors

Cited Authors

  • Kourany, WM; Miro, JM; Moreno, A; Corey, GR; Pappas, PA; Abrutyn, E; Hoen, B; Habib, G; Fowler, VG; Sexton, DJ; Olaison, L; Cabell, CH; ICE MD Investigators,

Published Date

  • January 2006

Published In

Volume / Issue

  • 38 / 8

Start / End Page

  • 613 - 619

PubMed ID

  • 16857604

Pubmed Central ID

  • 16857604

Electronic International Standard Serial Number (EISSN)

  • 1651-1980

International Standard Serial Number (ISSN)

  • 0036-5548

Digital Object Identifier (DOI)

  • 10.1080/00365540600617017

Language

  • eng