Pleiotropic signaling pathways orchestrate yeast development.

Journal Article (Journal Article;Review)

Developmental phenotypes in Saccharomyces cerevisiae and related yeasts include responses such as filamentous growth, sporulation, and the formation of biofilms and complex colonies. These developmental phenotypes are regulated by evolutionarily conserved, nutrient-responsive signaling networks. The signaling mechanisms that control development in yeast are highly pleiotropic--all the known pathways contribute to the regulation of multiple developmental outcomes. This degree of pleiotropy implies that perturbations of these signaling pathways, whether genetic, biochemical, or environmentally induced, can manifest in multiple (and sometimes unexpected) ways. We summarize the current state of knowledge of developmental pleiotropy in yeast and discuss its implications for understanding functional relationships.

Full Text

Duke Authors

Cited Authors

  • Granek, JA; Kayıkçı, Ö; Magwene, PM

Published Date

  • December 2011

Published In

Volume / Issue

  • 14 / 6

Start / End Page

  • 676 - 681

PubMed ID

  • 21962291

Pubmed Central ID

  • PMC3230781

Electronic International Standard Serial Number (EISSN)

  • 1879-0364

Digital Object Identifier (DOI)

  • 10.1016/j.mib.2011.09.004


  • eng

Conference Location

  • England