Morphological studies of the murine heart based on probabilistic and statistical atlases.


Journal Article

This study directly compares morphological features of the mouse heart in its end-relaxed state based on constructed morphometric maps and atlases using principal component analysis in C57BL/6J (n=8) and DBA (n=5) mice. In probabilistic atlases, a gradient probability exists for both strains in longitudinal locations from base to apex. Based on the statistical atlases, differences in size (49.8%), apical direction (15.6%), basal ventricular blood pool size (13.2%), and papillary muscle shape and position (17.2%) account for the most significant modes of shape variability for the left ventricle of the C57BL/6J mice. For DBA mice, differences in left ventricular size and direction (67.4%), basal size (15.7%), and position of papillary muscles (16.8%) account for significant variability.

Full Text

Duke Authors

Cited Authors

  • Perperidis, D; Bucholz, E; Johnson, GA; Constantinides, C

Published Date

  • March 2012

Published In

Volume / Issue

  • 36 / 2

Start / End Page

  • 119 - 129

PubMed ID

  • 21820867

Pubmed Central ID

  • 21820867

Electronic International Standard Serial Number (EISSN)

  • 1879-0771

Digital Object Identifier (DOI)

  • 10.1016/j.compmedimag.2011.07.001


  • eng

Conference Location

  • United States