Increased in vivo glucose recovery via nitric oxide release.


Journal Article (Letter)

The in vivo glucose recovery of subcutaneously implanted nitric oxide (NO)-releasing microdialysis probes was evaluated in a rat model using saturated NO solutions to steadily release NO. Such methodology resulted in a constant NO flux of 162 pmol cm(-2) s(-1) from the probe membrane over 8 h of perfusion daily. The in vivo effects of enhanced localized NO were evaluated by monitoring glucose recovery over a 14 day period, with histological analysis thereafter. A difference in glucose recovery was observed starting at 7 days for probes releasing NO relative to controls. Histological analysis at 14 days revealed lessened inflammatory cell density at the probe surface and decreased capsule thickness. Collectively, the results suggest that intermittent sustained NO release from implant surfaces may improve glucose diffusion for subcutaneously implanted sensors by mitigating the foreign body reaction.

Full Text

Duke Authors

Cited Authors

  • Nichols, SP; Le, NN; Klitzman, B; Schoenfisch, MH

Published Date

  • February 15, 2011

Published In

Volume / Issue

  • 83 / 4

Start / End Page

  • 1180 - 1184

PubMed ID

  • 21235247

Pubmed Central ID

  • 21235247

Electronic International Standard Serial Number (EISSN)

  • 1520-6882

Digital Object Identifier (DOI)

  • 10.1021/ac103070t


  • eng

Conference Location

  • United States