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Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents.

Publication ,  Journal Article
Badea, CT; Hedlund, LW; De Lin, M; Boslego Mackel, JF; Johnson, GA
Published in: Contrast Media Mol Imaging
2006

X-ray based micro-computed tomography (CT) and micro-digital subtraction angiography (DSA) are important non-invasive imaging modalities for following tumorogenesis in small animals. To exploit these imaging capabilities further, the two modalities were combined into a single system to provide both morphological and functional data from the same tumor in a single imaging session. The system is described and examples are given of imaging implanted fibrosarcoma tumors in rats using two types of contrast media: (a) a new generation of blood pool contrast agent containing iodine with a concentration of 130 mg/mL (Fenestratrade mark VC, Alerion Biomedical, San Diego, CA, USA) for micro-CT and (b) a conventional iodinated contrast agent (Isovue(R)-370 mg/mL iodine, trademark of Bracco Diagnostics, Princeton, NJ, USA) for micro-DSA. With the blood pool contrast agent, the 3D vascular architecture is revealed in exquisite detail at 100 microm resolution. Micro-DSA images, in perfect registration with the 3D micro-CT datasets, provide complementary functional information such as mean transit times and relative blood flow through the tumor. This imaging approach could be used to understand tumor angiogenesis better and be the basis for evaluating anti-angiogenic therapies.

Duke Scholars

Published In

Contrast Media Mol Imaging

DOI

EISSN

1555-4317

Publication Date

2006

Volume

1

Issue

4

Start / End Page

153 / 164

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Rats, Inbred F344
  • Rats
  • Nuclear Medicine & Medical Imaging
  • Iodine
  • Fibrosarcoma
  • Contrast Media
  • Animals
  • Angiography, Digital Subtraction
  • 4003 Biomedical engineering
 

Citation

APA
Chicago
ICMJE
MLA
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Badea, C. T., Hedlund, L. W., De Lin, M., Boslego Mackel, J. F., & Johnson, G. A. (2006). Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents. Contrast Media Mol Imaging, 1(4), 153–164. https://doi.org/10.1002/cmmi.103
Badea, Cristian T., Laurence W. Hedlund, Ming De Lin, Julie F. Boslego Mackel, and G Allan Johnson. “Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents.Contrast Media Mol Imaging 1, no. 4 (2006): 153–64. https://doi.org/10.1002/cmmi.103.
Badea CT, Hedlund LW, De Lin M, Boslego Mackel JF, Johnson GA. Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents. Contrast Media Mol Imaging. 2006;1(4):153–64.
Badea, Cristian T., et al. “Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents.Contrast Media Mol Imaging, vol. 1, no. 4, 2006, pp. 153–64. Pubmed, doi:10.1002/cmmi.103.
Badea CT, Hedlund LW, De Lin M, Boslego Mackel JF, Johnson GA. Tumor imaging in small animals with a combined micro-CT/micro-DSA system using iodinated conventional and blood pool contrast agents. Contrast Media Mol Imaging. 2006;1(4):153–164.
Journal cover image

Published In

Contrast Media Mol Imaging

DOI

EISSN

1555-4317

Publication Date

2006

Volume

1

Issue

4

Start / End Page

153 / 164

Location

England

Related Subject Headings

  • Tomography, X-Ray Computed
  • Rats, Inbred F344
  • Rats
  • Nuclear Medicine & Medical Imaging
  • Iodine
  • Fibrosarcoma
  • Contrast Media
  • Animals
  • Angiography, Digital Subtraction
  • 4003 Biomedical engineering