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Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.

Publication ,  Journal Article
Samei, E; Saunders, RS; Badea, CT; Ghaghada, KB; Hedlund, LW; Qi, Y; Yuan, H; Bentley, RC; Mukundan, S
Published in: Int J Nanomedicine
2009

A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.

Duke Scholars

Published In

Int J Nanomedicine

EISSN

1178-2013

Publication Date

2009

Volume

4

Start / End Page

277 / 282

Location

New Zealand

Related Subject Headings

  • Tomography, X-Ray Computed
  • Rats, Inbred F344
  • Rats
  • Radiographic Image Enhancement
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Mammography
  • Mammary Neoplasms, Animal
  • Liposomes
  • Iopamidol
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Samei, E., Saunders, R. S., Badea, C. T., Ghaghada, K. B., Hedlund, L. W., Qi, Y., … Mukundan, S. (2009). Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent. Int J Nanomedicine, 4, 277–282.
Samei, Ehsan, Robert S. Saunders, Cristian T. Badea, Ketan B. Ghaghada, Laurence W. Hedlund, Yi Qi, Hong Yuan, Rex C. Bentley, and Srinivasan Mukundan. “Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.Int J Nanomedicine 4 (2009): 277–82.
Samei E, Saunders RS, Badea CT, Ghaghada KB, Hedlund LW, Qi Y, et al. Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent. Int J Nanomedicine. 2009;4:277–82.
Samei, Ehsan, et al. “Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.Int J Nanomedicine, vol. 4, 2009, pp. 277–82.
Samei E, Saunders RS, Badea CT, Ghaghada KB, Hedlund LW, Qi Y, Yuan H, Bentley RC, Mukundan S. Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent. Int J Nanomedicine. 2009;4:277–282.

Published In

Int J Nanomedicine

EISSN

1178-2013

Publication Date

2009

Volume

4

Start / End Page

277 / 282

Location

New Zealand

Related Subject Headings

  • Tomography, X-Ray Computed
  • Rats, Inbred F344
  • Rats
  • Radiographic Image Enhancement
  • Nanoscience & Nanotechnology
  • Nanoparticles
  • Mammography
  • Mammary Neoplasms, Animal
  • Liposomes
  • Iopamidol