Micro-CT imaging of breast tumors in rodents using a liposomal, nanoparticle contrast agent.

Journal Article (Journal Article)

A long circulating liposomal, nanoscale blood pool agent encapsulating traditional iodinated contrast agent (65 mg I/mL) was used for micro-computed tomography (CT) imaging of rats implanted with R3230AC mammary carcinoma. Three-dimensional vascular architecture of tumors was imaged at 100-micron isotropic resolution. The image data showed good qualitative correlation with pathologic findings. The approach holds promise for studying tumor angiogenesis and for evaluating anti-angiogenesis therapies.

Full Text

Duke Authors

Cited Authors

  • Samei, E; Saunders, RS; Badea, CT; Ghaghada, KB; Hedlund, LW; Qi, Y; Yuan, H; Bentley, RC; Mukundan, S

Published Date

  • 2009

Published In

Volume / Issue

  • 4 /

Start / End Page

  • 277 - 282

PubMed ID

  • 20011244

Pubmed Central ID

  • PMC2789439

Electronic International Standard Serial Number (EISSN)

  • 1178-2013


  • eng

Conference Location

  • New Zealand