Imaging methods for morphological and functional phenotyping of the rodent heart.
Journal Article
Small animal imaging has a critical role in phenotyping, drug discovery, and in providing a basic understanding of mechanisms of disease. Translating imaging methods from humans to small animals is not an easy task. The purpose of this work is to compare two cardiac imaging modalities, i.e., magnetic resonance microscopy (MRM) and microcomputed tomography (CT) for preclinical studies on rodents. We present the two technologies, the parameters that they can measure, the types of alterations that they can detect, and show how these imaging methods compare to techniques available in clinical medicine. While this paper does not refer per se to the cardiac risk assessment for drug or chemical development, we hope that the information will effectively address how MRM and micro-CT might be exploited to measure biomarkers critical for safety assessment.
Full Text
Duke Authors
Cited Authors
- Badea, CT; Bucholz, E; Hedlund, LW; Rockman, HA; Johnson, GA
Published Date
- 2006
Published In
Volume / Issue
- 34 / 1
Start / End Page
- 111 - 117
PubMed ID
- 16507552
Pubmed Central ID
- 16507552
International Standard Serial Number (ISSN)
- 0192-6233
Digital Object Identifier (DOI)
- 10.1080/01926230500404126
Language
- eng
Conference Location
- United States