Targeting the epigenome in ovarian cancer.

Journal Article (Journal Article;Review)

Epithelial ovarian cancer is the leading cause of death from gynecological cancers, largely owing to the development of recurrent intractable disease. Only a small number of distinct genetic mutations are known to contribute to ovarian carcinogenesis. Furthermore, understanding mechanistic genotype-phenotype links is complicated by frequent aneuploidy. Epigenetic deregulation is even more prominent, and ovarian cancers are replete with such aberrations that repress tumor suppressors and activate proto-oncogenes. Epigenetic therapies are emerging as promising agents for resensitizing platinum-resistant ovarian cancers. These drugs may also have the potential to alter epigenetic programming in cancer progenitor cells and provide a strategy for improving therapy of ovarian cancer.

Full Text

Duke Authors

Cited Authors

  • Murphy, SK

Published Date

  • February 2012

Published In

Volume / Issue

  • 8 / 2

Start / End Page

  • 151 - 164

PubMed ID

  • 22335580

Electronic International Standard Serial Number (EISSN)

  • 1744-8301

Digital Object Identifier (DOI)

  • 10.2217/fon.11.152

Language

  • eng

Conference Location

  • England