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Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI.

Publication ,  Journal Article
Driehuys, B; Cofer, GP; Pollaro, J; Mackel, JB; Hedlund, LW; Johnson, GA
Published in: Proc Natl Acad Sci U S A
November 28, 2006

Effective pulmonary gas exchange relies on the free diffusion of gases across the thin tissue barrier separating airspace from the capillary red blood cells (RBCs). Pulmonary pathologies, such as inflammation, fibrosis, and edema, which cause an increased blood-gas barrier thickness, impair the efficiency of this exchange. However, definitive assessment of such gas-exchange abnormalities is challenging, because no methods currently exist to directly image the gas transfer process. Here we exploit the solubility and chemical shift of (129)Xe, the magnetic resonance signal of which has been enhanced by 10(5) with hyperpolarization, to differentially image its transfer from the airspaces into the tissue barrier spaces and RBCs in the gas exchange regions of the lung. Based on a simple diffusion model, we estimate that this MR imaging method for measuring (129)Xe alveolar-capillary transfer is sensitive to changes in blood-gas barrier thickness of approximately 5 microm. We validate the successful separation of tissue barrier and RBC images and show the utility of this method in a rat model of pulmonary fibrosis where (129)Xe replenishment of the RBCs is severely impaired in regions of lung injury.

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Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

November 28, 2006

Volume

103

Issue

48

Start / End Page

18278 / 18283

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Respiration
  • Rats, Inbred F344
  • Rats
  • Oxygen
  • Microcirculation
  • Magnetic Resonance Imaging
  • Erythrocytes
  • Animals
 

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Driehuys, B., Cofer, G. P., Pollaro, J., Mackel, J. B., Hedlund, L. W., & Johnson, G. A. (2006). Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proc Natl Acad Sci U S A, 103(48), 18278–18283. https://doi.org/10.1073/pnas.0608458103
Driehuys, Bastiaan, Gary P. Cofer, Jim Pollaro, Julie Boslego Mackel, Laurence W. Hedlund, and G Allan Johnson. “Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI.Proc Natl Acad Sci U S A 103, no. 48 (November 28, 2006): 18278–83. https://doi.org/10.1073/pnas.0608458103.
Driehuys B, Cofer GP, Pollaro J, Mackel JB, Hedlund LW, Johnson GA. Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18278–83.
Driehuys, Bastiaan, et al. “Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI.Proc Natl Acad Sci U S A, vol. 103, no. 48, Nov. 2006, pp. 18278–83. Pubmed, doi:10.1073/pnas.0608458103.
Driehuys B, Cofer GP, Pollaro J, Mackel JB, Hedlund LW, Johnson GA. Imaging alveolar-capillary gas transfer using hyperpolarized 129Xe MRI. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18278–18283.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

November 28, 2006

Volume

103

Issue

48

Start / End Page

18278 / 18283

Location

United States

Related Subject Headings

  • Xenon Isotopes
  • Respiration
  • Rats, Inbred F344
  • Rats
  • Oxygen
  • Microcirculation
  • Magnetic Resonance Imaging
  • Erythrocytes
  • Animals