Cine magnetic resonance microscopy of the rat heart using cardiorespiratory-synchronous projection reconstruction.
Journal Article (Journal Article)
PURPOSE: To tailor a cardiac magnetic resonance (MR) microscopy technique for the rat that combines improvements in pulse sequence design and physiologic control to acquire high-resolution images of cardiac structure and function. MATERIALS AND METHODS: Projection reconstruction (PR) was compared to conventional Cartesian techniques in point-spread function simulations and experimental studies to evaluate its artifact sensitivity. Female Sprague-Dawley rats were imaged at 2.0 T using PR with direct encoding of the free induction decay. Specialized physiologic support and monitoring equipment ensured consistency of biological motion and permitted synchronization of imaging with the cardiac and respiratory cycles. RESULTS: The reduced artifact sensitivity of PR offered improved delineation of cardiac and pulmonary structures. Ventilatory synchronization further increased the signal-to-noise ratio by reducing inter-view variability. High-quality short-axis and long-axis cine images of the rat heart were acquired with 10-msec temporal resolution and microscopic spatial resolution down to 175 microm x 175 microm x 1 mm. CONCLUSION: Integrating careful biological control with an optimized pulse sequence significantly limits both the source and impact of image artifacts. This work represents a novel integration of techniques designed to support measurement of cardiac morphology and function in rodent models of cardiovascular disease.
Full Text
Duke Authors
Cited Authors
- Brau, ACS; Hedlund, LW; Johnson, GA
Published Date
- July 1, 2004
Published In
Volume / Issue
- 20 / 1
Start / End Page
- 31 - 38
PubMed ID
- 15221806
International Standard Serial Number (ISSN)
- 1053-1807
Digital Object Identifier (DOI)
- 10.1002/jmri.20089
Language
- eng
Conference Location
- United States