Ventilation/perfusion imaging in a rat model of airway obstruction.

Journal Article (Journal Article)

The global increase in asthma, chronic obstructive pulmonary disease, and other pulmonary diseases has stimulated interest in preclinical rat models of pulmonary disease. Imaging methods for study of these models is particularly appealing since the results can be readily translated to the clinical setting. Comprehensive understanding of lung function can be achieved by performing registered pulmonary ventilation and perfusion imaging studies in the same animal. While ventilation imaging has been addressed for small animals, quantitative pulmonary perfusion imaging has not been feasible until recently, with our proposed technique for quantitative perfusion imaging using multiple contrast-agent injections and a view-sharing radial imaging technique. Here, we combine the method with registered ventilation imaging using hyperpolarized (3)He in an airway obstruction rodent model. To our knowledge, this is the first comprehensive quantitative assessment of lung function in small animals at high spatial resolution. Standard deviation of the log (V/Q) is used as a quantitative biomarker to differentiate heterogeneity between the control and treatment group. The estimated value of the biomarker lies within the normal range of values reported in the literature. The biomarker that was extracted using the imaging technique described in this work showed statistically significant differences between the control rats and those with airway obstruction.

Full Text

Duke Authors

Cited Authors

  • Mistry, NN; Qi, Y; Hedlund, LW; Johnson, GA

Published Date

  • March 2010

Published In

Volume / Issue

  • 63 / 3

Start / End Page

  • 728 - 735

PubMed ID

  • 20146375

Pubmed Central ID

  • PMC2832088

Electronic International Standard Serial Number (EISSN)

  • 1522-2594

Digital Object Identifier (DOI)

  • 10.1002/mrm.22221


  • eng

Conference Location

  • United States