Imaging techniques for small animal models of pulmonary disease: MR microscopy.

Journal Article (Journal Article)

In vivo magnetic resonance microscopy (MRM) of the small animal lung has become a valuable research tool, especially for preclinical studies. MRM offers a noninvasive and nondestructive tool for imaging small animals longitudinally and at high spatial resolution. We summarize some of the technical and biologic problems and solutions associated with imaging the small animal lung and describe several important pulmonary disease applications. A major advantage of MR is direct imaging of the gas spaces of the lung using breathable gases such as helium and xenon. When polarized, these gases become rich MR signal sources. In animals breathing hyperpolarized helium, the dynamics of gas distribution can be followed and airway constrictions and obstructions can be detected. Diffusion coefficients of helium can be calculated from diffusion-sensitive images, which can reveal micro-structural changes in the lungs associated with pathologies such as emphysema and fibrosis. Unlike helium, xenon in the lung is absorbed by blood and exhibits different frequencies in gas, tissue, or erythrocytes. Thus, with MR imaging, the movement of xenon gas can be tracked through pulmonary compartments to detect defects of gas transfer. MRM has become a valuable tool for studying morphologic and functional changes in small animal models of lung diseases.

Full Text

Duke Authors

Cited Authors

  • Driehuys, B; Hedlund, LW

Published Date

  • January 1, 2007

Published In

Volume / Issue

  • 35 / 1

Start / End Page

  • 49 - 58

PubMed ID

  • 17325972

Pubmed Central ID

  • PMC2747380

International Standard Serial Number (ISSN)

  • 0192-6233

Digital Object Identifier (DOI)

  • 10.1080/01926230601132048


  • eng

Conference Location

  • United States