Uncertainty, symptoms, and quality of life in persons with chronic hepatitis C.


Journal Article

BACKGROUND: Chronic hepatitis C (CHC) is the most common blood-borne infection in the United States, but little is known about illness uncertainty in these patients. OBJECTIVE: The authors examined the constructs of illness uncertainty. METHOD: In this cross-sectional study, Mishel's Uncertainty in Illness Scale was used to examine these constructs (ambiguity, complexity, inconsistency, unpredictability) and their relationships with fatigue, pain, depressive symptoms, comorbidity, and quality of life (QOL) in 126 CHC patients undergoing a watchful-waiting protocol. RESULTS: The Ambiguity subscale had the strongest relationships with depressive symptoms, QOL, and fatigue, and three of the four subscales were significantly correlated with pain. CONCLUSION: The results suggest targets for patient self-management interventions.

Full Text

Duke Authors

Cited Authors

  • Bailey, DE; Landerman, L; Barroso, J; Bixby, P; Mishel, MH; Muir, AJ; Strickland, L; Clipp, E

Published Date

  • March 2009

Published In

Volume / Issue

  • 50 / 2

Start / End Page

  • 138 - 146

PubMed ID

  • 19377022

Pubmed Central ID

  • 19377022

Electronic International Standard Serial Number (EISSN)

  • 1545-7206

Digital Object Identifier (DOI)

  • 10.1176/appi.psy.50.2.138


  • eng

Conference Location

  • England