Acute allograft rejection: cellular and humoral processes.

Journal Article (Journal Article)

Acute cellular rejection affects greater than one-third of lung transplant recipients. Alloreactive T-lymphocytes constitute the basis of lung allograft rejection. Recent evidence supports a more complex immune response to the allograft. Interaction between recipient genetics, immunosuppression therapies, and allograft environmental exposures likely contribute to high rejection rates after lung transplantation. A greater understanding of the heterogeneous mechanisms of lung rejection is critical to developing effective therapies that target the precise pathophysiology of the disease and ultimately improve long-term lung transplant outcomes.

Full Text

Duke Authors

Cited Authors

  • Martinu, T; Pavlisko, EN; Chen, D-F; Palmer, SM

Published Date

  • June 2011

Published In

Volume / Issue

  • 32 / 2

Start / End Page

  • 295 - 310

PubMed ID

  • 21511091

Pubmed Central ID

  • PMC3089893

Electronic International Standard Serial Number (EISSN)

  • 1557-8216

Digital Object Identifier (DOI)

  • 10.1016/j.ccm.2011.02.008


  • eng

Conference Location

  • United States