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Bronchiolitis obliterans syndrome: the final frontier for lung transplantation.

Publication ,  Journal Article
Todd, JL; Palmer, SM
Published in: Chest
August 2011

Bronchiolitis obliterans syndrome (BOS) is a form of chronic lung allograft dysfunction that affects a majority of lung transplant recipients and is the principal factor limiting long-term transplant survival. BOS is characterized by progressive airflow obstruction unexplained by acute rejection, infection, or other coexistent condition. Although BOS is a proven useful clinical syndrome that identifies patients at increased risk for death, its clinical course and underlying causative factors are now recognized to be increasingly heterogeneous. Regardless of the clinical history, the primary pathologic correlate of BOS is bronchiolitis obliterans, a condition of intraluminal airway fibrosis. This article highlights the body of developing research illustrating the mechanisms by which BOS is mediated, including alloimmune reactivity, the emerging roles of humoral and autoimmunity, activation of innate immune cells, and response to nonimmune-related allograft insults, such as infection and aspiration. In addition, we underscore emerging clinical implications and promising future translational research directions that have the potential to advance our knowledge and improve patient outcomes.

Duke Scholars

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Published In

Chest

DOI

EISSN

1931-3543

Publication Date

August 2011

Volume

140

Issue

2

Start / End Page

502 / 508

Location

United States

Related Subject Headings

  • Risk Factors
  • Respiratory System
  • Lung Transplantation
  • Immunity, Innate
  • Immunity, Humoral
  • Humans
  • Bronchiolitis Obliterans
  • Autoimmunity
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
 

Citation

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Todd, J. L., & Palmer, S. M. (2011). Bronchiolitis obliterans syndrome: the final frontier for lung transplantation. Chest, 140(2), 502–508. https://doi.org/10.1378/chest.10-2838
Todd, Jamie L., and Scott M. Palmer. “Bronchiolitis obliterans syndrome: the final frontier for lung transplantation.Chest 140, no. 2 (August 2011): 502–8. https://doi.org/10.1378/chest.10-2838.
Todd, Jamie L., and Scott M. Palmer. “Bronchiolitis obliterans syndrome: the final frontier for lung transplantation.Chest, vol. 140, no. 2, Aug. 2011, pp. 502–08. Pubmed, doi:10.1378/chest.10-2838.
Todd JL, Palmer SM. Bronchiolitis obliterans syndrome: the final frontier for lung transplantation. Chest. 2011 Aug;140(2):502–508.

Published In

Chest

DOI

EISSN

1931-3543

Publication Date

August 2011

Volume

140

Issue

2

Start / End Page

502 / 508

Location

United States

Related Subject Headings

  • Risk Factors
  • Respiratory System
  • Lung Transplantation
  • Immunity, Innate
  • Immunity, Humoral
  • Humans
  • Bronchiolitis Obliterans
  • Autoimmunity
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology