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Ambient ozone and pulmonary innate immunity.

Publication ,  Journal Article
Al-Hegelan, M; Tighe, RM; Castillo, C; Hollingsworth, JW
Published in: Immunol Res
April 2011

Ambient ozone is a criteria air pollutant that impacts both human morbidity and mortality. The effect of ozone inhalation includes both toxicity to lung tissue and alteration of the host immunologic response. The innate immune system facilitates immediate recognition of both foreign pathogens and tissue damage. Emerging evidence supports that ozone can modify the host innate immune response and that this response to inhaled ozone is dependent on genes of innate immunity. Improved understanding of the complex interaction between environmental ozone and host innate immunity will provide fundamental insight into the pathogenesis of inflammatory airways disease. We review the current evidence supporting that environmental ozone inhalation: (1) modifies cell types required for intact innate immunity, (2) is partially dependent on genes of innate immunity, (3) primes pulmonary innate immune responses to LPS, and (4) contributes to innate-adaptive immune system cross-talk.

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Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

173 / 191

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Ozone
  • Lung
  • Immunology
  • Immunity, Innate
  • Humans
  • Animals
  • Air Pollutants
  • Adaptive Immunity
  • 3204 Immunology
 

Citation

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Al-Hegelan, M., Tighe, R. M., Castillo, C., & Hollingsworth, J. W. (2011). Ambient ozone and pulmonary innate immunity. Immunol Res, 49(1–3), 173–191. https://doi.org/10.1007/s12026-010-8180-z
Al-Hegelan, Mashael, Robert M. Tighe, Christian Castillo, and John W. Hollingsworth. “Ambient ozone and pulmonary innate immunity.Immunol Res 49, no. 1–3 (April 2011): 173–91. https://doi.org/10.1007/s12026-010-8180-z.
Al-Hegelan M, Tighe RM, Castillo C, Hollingsworth JW. Ambient ozone and pulmonary innate immunity. Immunol Res. 2011 Apr;49(1–3):173–91.
Al-Hegelan, Mashael, et al. “Ambient ozone and pulmonary innate immunity.Immunol Res, vol. 49, no. 1–3, Apr. 2011, pp. 173–91. Pubmed, doi:10.1007/s12026-010-8180-z.
Al-Hegelan M, Tighe RM, Castillo C, Hollingsworth JW. Ambient ozone and pulmonary innate immunity. Immunol Res. 2011 Apr;49(1–3):173–191.
Journal cover image

Published In

Immunol Res

DOI

EISSN

1559-0755

Publication Date

April 2011

Volume

49

Issue

1-3

Start / End Page

173 / 191

Location

United States

Related Subject Headings

  • Toll-Like Receptors
  • Ozone
  • Lung
  • Immunology
  • Immunity, Innate
  • Humans
  • Animals
  • Air Pollutants
  • Adaptive Immunity
  • 3204 Immunology