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Encoded multichromophore response for simultaneous label-free detection.

Publication ,  Journal Article
Pistol, C; Mao, V; Thusu, V; Lebeck, AR; Dwyer, C
Published in: Small (Weinheim an der Bergstrasse, Germany)
April 2010

The self-assembly of molecularly precise nanostructures is widely expected to form the basis of future high-speed integrated circuits, but the technologies suitable for such circuits are not well understood. In this work, DNA self-assembly is used to create molecular logic circuits that can selectively identify specific biomolecules in solution by encoding the optical response of near-field coupled arrangements of chromophores. The resulting circuits can detect label-free, femtomole quantities of multiple proteins, DNA oligomers, and small fragments of RNA in solution via ensemble optical measurements. This method, which is capable of creating multiple logic-gate-sensor pairs on a 2 x 80 x 80-nm DNA grid, is a step toward more sophisticated nanoscale logic circuits capable of interfacing computers with biological processes.

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Published In

Small (Weinheim an der Bergstrasse, Germany)

DOI

EISSN

1613-6829

ISSN

1613-6810

Publication Date

April 2010

Volume

6

Issue

7

Start / End Page

843 / 850

Related Subject Headings

  • Staining and Labeling
  • RNA
  • Proteins
  • Optical Phenomena
  • Nanoscience & Nanotechnology
  • Microscopy, Atomic Force
  • Fluorescent Dyes
  • DNA
  • Biosensing Techniques
 

Citation

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Pistol, C., Mao, V., Thusu, V., Lebeck, A. R., & Dwyer, C. (2010). Encoded multichromophore response for simultaneous label-free detection. Small (Weinheim an Der Bergstrasse, Germany), 6(7), 843–850. https://doi.org/10.1002/smll.200901996
Pistol, Constantin, Vincent Mao, Viresh Thusu, Alvin R. Lebeck, and Chris Dwyer. “Encoded multichromophore response for simultaneous label-free detection.Small (Weinheim an Der Bergstrasse, Germany) 6, no. 7 (April 2010): 843–50. https://doi.org/10.1002/smll.200901996.
Pistol C, Mao V, Thusu V, Lebeck AR, Dwyer C. Encoded multichromophore response for simultaneous label-free detection. Small (Weinheim an der Bergstrasse, Germany). 2010 Apr;6(7):843–50.
Pistol, Constantin, et al. “Encoded multichromophore response for simultaneous label-free detection.Small (Weinheim an Der Bergstrasse, Germany), vol. 6, no. 7, Apr. 2010, pp. 843–50. Epmc, doi:10.1002/smll.200901996.
Pistol C, Mao V, Thusu V, Lebeck AR, Dwyer C. Encoded multichromophore response for simultaneous label-free detection. Small (Weinheim an der Bergstrasse, Germany). 2010 Apr;6(7):843–850.
Journal cover image

Published In

Small (Weinheim an der Bergstrasse, Germany)

DOI

EISSN

1613-6829

ISSN

1613-6810

Publication Date

April 2010

Volume

6

Issue

7

Start / End Page

843 / 850

Related Subject Headings

  • Staining and Labeling
  • RNA
  • Proteins
  • Optical Phenomena
  • Nanoscience & Nanotechnology
  • Microscopy, Atomic Force
  • Fluorescent Dyes
  • DNA
  • Biosensing Techniques