Encoded multichromophore response for simultaneous label-free detection.

Journal Article (Journal Article)

The self-assembly of molecularly precise nanostructures is widely expected to form the basis of future high-speed integrated circuits, but the technologies suitable for such circuits are not well understood. In this work, DNA self-assembly is used to create molecular logic circuits that can selectively identify specific biomolecules in solution by encoding the optical response of near-field coupled arrangements of chromophores. The resulting circuits can detect label-free, femtomole quantities of multiple proteins, DNA oligomers, and small fragments of RNA in solution via ensemble optical measurements. This method, which is capable of creating multiple logic-gate-sensor pairs on a 2 x 80 x 80-nm DNA grid, is a step toward more sophisticated nanoscale logic circuits capable of interfacing computers with biological processes.

Full Text

Duke Authors

Cited Authors

  • Pistol, C; Mao, V; Thusu, V; Lebeck, AR; Dwyer, C

Published Date

  • April 2010

Published In

Volume / Issue

  • 6 / 7

Start / End Page

  • 843 - 850

PubMed ID

  • 20349447

Electronic International Standard Serial Number (EISSN)

  • 1613-6829

International Standard Serial Number (ISSN)

  • 1613-6810

Digital Object Identifier (DOI)

  • 10.1002/smll.200901996


  • eng