Long-term exposure of chemokine CXCL10 causes bronchiolitis-like inflammation.

Published

Journal Article

Chemokines and chemokine receptors have been implicated in the pathogenesis of bronchiolitis. CXCR3 ligands (CXCL10, CXCL9, and CXCL11) were elevated in patients with bronchiolitis obliterans syndrome (BOS) and chronic allorejection. Studies also suggested that blockage of CXCR3 or its ligands changed the outcome of T-cell recruitment and airway obliteration. We wanted to determine the role of the chemokine CXCL10 in the pathogenesis of bronchiolitis and BOS. In this study, we found that CXCL10 mRNA levels were significantly increased in patients with BOS. We generated transgenic mice expressing a mouse CXCL10 cDNA under control of the rat CC10 promoter. Six-month-old CC10-CXCL10 transgenic mice developed bronchiolitis characterized by airway epithelial hyperplasia and developed peribronchiolar and perivascular lymphocyte infiltration. The airway hyperplasia and T-cell inflammation were dependent on the presence of CXCR3. Therefore, long-term exposure of the chemokine CXCL10 in the lung causes bronchiolitis-like inflammation in mice.

Full Text

Duke Authors

Cited Authors

  • Jiang, D; Liang, J; Guo, R; Xie, T; Kelly, FL; Martinu, T; Yang, T; Lovgren, AK; Chia, J; Liu, N; Jung, Y; Palmer, SM; Noble, PW

Published Date

  • May 2012

Published In

Volume / Issue

  • 46 / 5

Start / End Page

  • 592 - 598

PubMed ID

  • 22162905

Pubmed Central ID

  • 22162905

Electronic International Standard Serial Number (EISSN)

  • 1535-4989

Digital Object Identifier (DOI)

  • 10.1165/rcmb.2011-0116OC

Language

  • eng

Conference Location

  • United States