The Valley of Death in anticancer drug development: a reassessment.

Published

Journal Article (Review)

The past decade has seen an explosion in our understanding of cancer biology and with it many new potential disease targets. Nonetheless, our ability to translate these advances into therapies is poor, with a failure rate approaching 90%. Much discussion has been devoted to this so-called 'Valley of Death' in anticancer drug development, but the problem persists. Could we have overlooked some straightforward explanations to this highly complex problem? Important aspects of tumor physiology, drug pharmacokinetics, preclinical models, drug delivery, and clinical translation are not often emphasized, but could be crucial. This perspective summarizes current views on the problem and suggests feasible alternatives.

Full Text

Duke Authors

Cited Authors

  • Adams, DJ

Published Date

  • April 2012

Published In

Volume / Issue

  • 33 / 4

Start / End Page

  • 173 - 180

PubMed ID

  • 22410081

Pubmed Central ID

  • 22410081

Electronic International Standard Serial Number (EISSN)

  • 1873-3735

International Standard Serial Number (ISSN)

  • 0165-6147

Digital Object Identifier (DOI)

  • 10.1016/j.tips.2012.02.001

Language

  • eng