Centromeres poised en pointe: CDKs put a hold on CENP-A assembly.

Journal Article (Journal Article)

Eukaryotic centromeres are propagated by incorporation of the centromere-specific histone CENP-A into centromeric chromatin. Silva et al. (2012) now show that cyclin-dependent kinases (CDKs) hold the CENP-A assembly machinery in an inactive state until mitotic exit and entry into G1, at which time new CENP-A is loaded.

Full Text

Duke Authors

Cited Authors

  • Stimpson, KM; Sullivan, BA

Published Date

  • January 17, 2012

Published In

Volume / Issue

  • 22 / 1

Start / End Page

  • 1 - 2

PubMed ID

  • 22264723

Electronic International Standard Serial Number (EISSN)

  • 1878-1551

Digital Object Identifier (DOI)

  • 10.1016/j.devcel.2011.12.013


  • eng

Conference Location

  • United States