Lipid profiles of pediatric hematopoietic stem cell transplant survivors.


Journal Article

Cardiovascular disease (CVD) is the leading cause of death among adults in the United States. CVD pathology, including abnormal lipid levels, may begin in childhood. Hematopoietic stem cell transplant (HSCT) survivors have increased risk of abnormal lipid levels, but there is limited information in children post-HSCT. The study aimed to describe lipid levels and identify the factors associated with dyslipidemia in pediatric HSCT survivors during the first 3 years post-HSCT. This descriptive research study used a retrospective chart review to assess lipid profiles among 31 pediatric HSCT patients. Mean lipid levels were within normal limits but contained large ranges in values. There was no statistically significant change over time; however, there was an increased trend of total cholesterol and low-density lipoprotein levels and a decreased trend of high-density lipoprotein levels. The majority of patients had one abnormal lipid level at 1 and 2 years post-HSCT. Body mass index was the only factor significantly associated with dyslipidemia. An awareness of dyslipidemia among HSCT survivors may allow for early identification and treatment of abnormal lipid levels.

Full Text

Duke Authors

Cited Authors

  • Rodgers, C; Gregurich, MA; Hockenberry, M

Published Date

  • March 13, 2012

Published In

Volume / Issue

  • 29 / 2

Start / End Page

  • 63 - 69

PubMed ID

  • 22415856

Pubmed Central ID

  • 22415856

Electronic International Standard Serial Number (EISSN)

  • 1532-8457

International Standard Serial Number (ISSN)

  • 1043-4542

Digital Object Identifier (DOI)

  • 10.1177/1043454212438404


  • eng