Role of aerobic fitness and aging on cerebral white matter integrity.

Journal Article (Journal Article)

Neuroimaging research suggests that cerebral white matter (WM) integrity, as reflected in fractional anisotropy (FA) via diffusion tensor imaging (DTI), is decreased in older adults, especially in the prefrontal regions of the brain. Behavioral investigations of cognitive functioning suggest that some aspects of cognition may be better preserved in older adults who possess higher levels of aerobic fitness. There are only a few studies, however, investigating potential mechanisms for the improvements in aerobic fitness. Our study suggests that greater aerobic fitness may be related to greater WM integrity in select brain regions.

Full Text

Duke Authors

Cited Authors

  • Marks, BL; Madden, DJ; Bucur, B; Provenzale, JM; White, LE; Cabeza, R; Huettel, SA

Published Date

  • February 2007

Published In

Volume / Issue

  • 1097 /

Start / End Page

  • 171 - 174

PubMed ID

  • 17413020

International Standard Serial Number (ISSN)

  • 0077-8923

Digital Object Identifier (DOI)

  • 10.1196/annals.1379.022


  • eng

Conference Location

  • United States