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Diffusion tensor imaging of cerebral white matter integrity in cognitive aging.

Publication ,  Journal Article
Madden, DJ; Bennett, IJ; Burzynska, A; Potter, GG; Chen, N-K; Song, AW
Published in: Biochim Biophys Acta
March 2012

In this article we review recent research on diffusion tensor imaging (DTI) of white matter (WM) integrity and the implications for age-related differences in cognition. Neurobiological mechanisms defined from DTI analyses suggest that a primary dimension of age-related decline in WM is a decline in the structural integrity of myelin, particularly in brain regions that myelinate later developmentally. Research integrating behavioral measures with DTI indicates that WM integrity supports the communication among cortical networks, particularly those involving executive function, perceptual speed, and memory (i.e., fluid cognition). In the absence of significant disease, age shares a substantial portion of the variance associated with the relation between WM integrity and fluid cognition. Current data are consistent with one model in which age-related decline in WM integrity contributes to a decreased efficiency of communication among networks for fluid cognitive abilities. Neurocognitive disorders for which older adults are at risk, such as depression, further modulate the relation between WM and cognition, in ways that are not as yet entirely clear. Developments in DTI technology are providing a new insight into both the neurobiological mechanisms of aging WM and the potential contribution of DTI to understanding functional measures of brain activity. This article is part of a Special Issue entitled: Imaging Brain Aging and Neurodegenerative disease.

Duke Scholars

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

March 2012

Volume

1822

Issue

3

Start / End Page

386 / 400

Location

Netherlands

Related Subject Headings

  • Nerve Fibers, Myelinated
  • Humans
  • Diffusion Tensor Imaging
  • Cognition Disorders
  • Cognition
  • Cerebrum
  • Age Factors
  • 51 Physical sciences
  • 31 Biological sciences
  • 06 Biological Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Madden, D. J., Bennett, I. J., Burzynska, A., Potter, G. G., Chen, N.-K., & Song, A. W. (2012). Diffusion tensor imaging of cerebral white matter integrity in cognitive aging. Biochim Biophys Acta, 1822(3), 386–400. https://doi.org/10.1016/j.bbadis.2011.08.003
Madden, David J., Ilana J. Bennett, Agnieszka Burzynska, Guy G. Potter, Nan-Kuei Chen, and Allen W. Song. “Diffusion tensor imaging of cerebral white matter integrity in cognitive aging.Biochim Biophys Acta 1822, no. 3 (March 2012): 386–400. https://doi.org/10.1016/j.bbadis.2011.08.003.
Madden DJ, Bennett IJ, Burzynska A, Potter GG, Chen N-K, Song AW. Diffusion tensor imaging of cerebral white matter integrity in cognitive aging. Biochim Biophys Acta. 2012 Mar;1822(3):386–400.
Madden, David J., et al. “Diffusion tensor imaging of cerebral white matter integrity in cognitive aging.Biochim Biophys Acta, vol. 1822, no. 3, Mar. 2012, pp. 386–400. Pubmed, doi:10.1016/j.bbadis.2011.08.003.
Madden DJ, Bennett IJ, Burzynska A, Potter GG, Chen N-K, Song AW. Diffusion tensor imaging of cerebral white matter integrity in cognitive aging. Biochim Biophys Acta. 2012 Mar;1822(3):386–400.

Published In

Biochim Biophys Acta

DOI

ISSN

0006-3002

Publication Date

March 2012

Volume

1822

Issue

3

Start / End Page

386 / 400

Location

Netherlands

Related Subject Headings

  • Nerve Fibers, Myelinated
  • Humans
  • Diffusion Tensor Imaging
  • Cognition Disorders
  • Cognition
  • Cerebrum
  • Age Factors
  • 51 Physical sciences
  • 31 Biological sciences
  • 06 Biological Sciences