BOLD signal compartmentalization based on the apparent diffusion coefficient.


Journal Article

Functional MRI (fMRI) can detect blood oxygenation level dependent (BOLD) hemodynamic responses secondary to neuronal activity. The most commonly used method for detecting fMRI signals is the gradient-echo echo-planar imaging (EPI) technique because of its sensitivity and speed. However, it is generally believed that a significant portion of these signals arises from large veins, with additional contribution from the capillaries and parenchyma. Early experiments using diffusion-weighted gradient-echo EPI have suggested that intra-voxel incoherent motion (IVIM) weighting inherent in the sequence can selectively attenuate contributions from different vessels based on the differences in the mobility of the blood within them. In the present study, we used similar approach to characterize the apparent diffusion coefficient (ADC) distribution within the activated areas of BOLD contrast. It is shown that the voxel values of the ADCs obtained from this technique can infer various vascular contributions to the BOLD signal.

Full Text

Duke Authors

Cited Authors

  • Song, AW; Fichtenholtz, H; Woldorff, M

Published Date

  • September 2002

Published In

Volume / Issue

  • 20 / 7

Start / End Page

  • 521 - 525

PubMed ID

  • 12413597

Pubmed Central ID

  • 12413597

International Standard Serial Number (ISSN)

  • 0730-725X

Digital Object Identifier (DOI)

  • 10.1016/s0730-725x(02)00516-7


  • eng

Conference Location

  • Netherlands