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Intraoperative floppy iris syndrome: report of a case and histopathologic analysis.

Publication ,  Journal Article
Panagis, L; Basile, M; Friedman, AH; Danias, J
Published in: Arch Ophthalmol
November 2010

OBJECTIVE: To understand the role of the α(1A)-adrenoreceptors (ARs) in the pathophysiologic mechanism of intraoperative floppy iris syndrome (IFIS). METHODS: Iris specimens from a patient with tamsulosin hydrochloride-induced IFIS were obtained during trabeculectomy. Specimens underwent histological analysis and immunohistochemical analysis with antibodies specific for actin, myoglobin, α(1A)-ARs, and myosin. Iris specimens from a patient without IFIS were used for comparison. Samples were processed for transmission electron microscopy. RESULTS: Histological examination showed normal dilator muscle, arterioles, stroma, and pigment epithelium. Actin, myosin, and myoglobin distribution and intensities were similar between IFIS and non-IFIS tissue. The staining pattern and colocalization with myosin suggested that α(1A)-ARs are present in iris arteriolar muscularis in addition to the dilator muscle in both IFIS and control irides. Significantly less staining of IFIS tissue was found compared with the non-IFIS iris. Ultrastructures of melanocytes and stroma appeared to be normal. Iris arterioles possessed thick endothelial basement membranes, semilongitudinally oriented muscularis, and abundant perivascular collagen coats. CONCLUSIONS: We confirm the presence of α(1A)-ARs in human iris by results of immunohistochemical analysis. The α(1A)-ARs localize to iris arteriolar muscularis in addition to the iris dilator muscle. This localization suggests that IFIS may develop because of iris vascular dysfunction and that iris vasculature may have structural in addition to nutritive functions.

Duke Scholars

Published In

Arch Ophthalmol

DOI

EISSN

1538-3601

Publication Date

November 2010

Volume

128

Issue

11

Start / End Page

1437 / 1441

Location

United States

Related Subject Headings

  • Trabeculectomy
  • Tamsulosin
  • Syndrome
  • Sulfonamides
  • Receptors, Adrenergic, alpha-1
  • Ophthalmology & Optometry
  • Myosins
  • Myoglobin
  • Microscopy, Electron, Transmission
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Panagis, L., Basile, M., Friedman, A. H., & Danias, J. (2010). Intraoperative floppy iris syndrome: report of a case and histopathologic analysis. Arch Ophthalmol, 128(11), 1437–1441. https://doi.org/10.1001/archophthalmol.2010.243
Panagis, Lampros, Maria Basile, Alan H. Friedman, and John Danias. “Intraoperative floppy iris syndrome: report of a case and histopathologic analysis.Arch Ophthalmol 128, no. 11 (November 2010): 1437–41. https://doi.org/10.1001/archophthalmol.2010.243.
Panagis L, Basile M, Friedman AH, Danias J. Intraoperative floppy iris syndrome: report of a case and histopathologic analysis. Arch Ophthalmol. 2010 Nov;128(11):1437–41.
Panagis, Lampros, et al. “Intraoperative floppy iris syndrome: report of a case and histopathologic analysis.Arch Ophthalmol, vol. 128, no. 11, Nov. 2010, pp. 1437–41. Pubmed, doi:10.1001/archophthalmol.2010.243.
Panagis L, Basile M, Friedman AH, Danias J. Intraoperative floppy iris syndrome: report of a case and histopathologic analysis. Arch Ophthalmol. 2010 Nov;128(11):1437–1441.

Published In

Arch Ophthalmol

DOI

EISSN

1538-3601

Publication Date

November 2010

Volume

128

Issue

11

Start / End Page

1437 / 1441

Location

United States

Related Subject Headings

  • Trabeculectomy
  • Tamsulosin
  • Syndrome
  • Sulfonamides
  • Receptors, Adrenergic, alpha-1
  • Ophthalmology & Optometry
  • Myosins
  • Myoglobin
  • Microscopy, Electron, Transmission
  • Male