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Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in vitro fertilization really increased?: a case-historical control study.

Publication ,  Journal Article
Bahtiyar, MO; Campbell, K; Dulay, AT; Kontic-Vucinic, O; Weeks, BP; Friedman, AH; Copel, JA
Published in: J Ultrasound Med
June 2010

OBJECTIVE: We investigated the prenatal prevalence of congenital heart defects (CHDs) among in vitro fertilization (IVF) pregnancies at a referral program in the United States. METHODS: Study patients were referred for fetal echocardiography between April 1, 2006, and May 1, 2009, due to IVF. An IVF pregnancy was defined as a patient who conceived with IVF with or without intracytoplasmic sperm injection. Congenital heart defect odds relative to historical data were calculated by standard methods. P < .05 was considered statistically significant. RESULTS: During the study period, we performed fetal echocardiography on 749 consecutive IVF pregnancies. Overall, the frequency of CHDs was 1.1% (95% confidence interval, 0.3%-1.8%) per pregnancy. Compared to earlier historical population data, IVF pregnancies had a significantly higher risk of CHDs (odds ratios, 7.3 [3.6-14.7] and 2.9 [1.4-5.9], respectively). However, compared to more contemporary population data, there was no difference in the CHD risk between IVF gestations and naturally conceived pregnancies. Further analysis indicated that IVF twin pregnancies were as much as 12.5 (4.6-33.5) times as likely to have CHDs compared to a general population. CONCLUSIONS: In this study population, the frequency of CHDs in IVF pregnancies was higher than early historical population data; however, it was similar to that of a more contemporary general population. Further analysis showed that this increase was mainly driven by IVF twin gestations. Previous reports of increased CHD risk in pregnancies conceived via IVF may have been due, in part, to an increased frequency of higher-order pregnancies seen among these patients.

Duke Scholars

Published In

J Ultrasound Med

DOI

EISSN

1550-9613

Publication Date

June 2010

Volume

29

Issue

6

Start / End Page

917 / 922

Location

England

Related Subject Headings

  • United States
  • Ultrasonography, Prenatal
  • Risk Factors
  • Prevalence
  • Pregnancy, Multiple
  • Pregnancy Outcome
  • Pregnancy
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Heart Defects, Congenital
 

Citation

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MLA
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Bahtiyar, M. O., Campbell, K., Dulay, A. T., Kontic-Vucinic, O., Weeks, B. P., Friedman, A. H., & Copel, J. A. (2010). Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in vitro fertilization really increased?: a case-historical control study. J Ultrasound Med, 29(6), 917–922. https://doi.org/10.7863/jum.2010.29.6.917
Bahtiyar, Mert Ozan, Katherine Campbell, Antonette T. Dulay, Olivera Kontic-Vucinic, Bevin P. Weeks, Alan H. Friedman, and Joshua A. Copel. “Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in vitro fertilization really increased?: a case-historical control study.J Ultrasound Med 29, no. 6 (June 2010): 917–22. https://doi.org/10.7863/jum.2010.29.6.917.
Bahtiyar MO, Campbell K, Dulay AT, Kontic-Vucinic O, Weeks BP, Friedman AH, et al. Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in vitro fertilization really increased?: a case-historical control study. J Ultrasound Med. 2010 Jun;29(6):917–22.
Bahtiyar, Mert Ozan, et al. “Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in vitro fertilization really increased?: a case-historical control study.J Ultrasound Med, vol. 29, no. 6, June 2010, pp. 917–22. Pubmed, doi:10.7863/jum.2010.29.6.917.
Bahtiyar MO, Campbell K, Dulay AT, Kontic-Vucinic O, Weeks BP, Friedman AH, Copel JA. Is the rate of congenital heart defects detected by fetal echocardiography among pregnancies conceived by in vitro fertilization really increased?: a case-historical control study. J Ultrasound Med. 2010 Jun;29(6):917–922.

Published In

J Ultrasound Med

DOI

EISSN

1550-9613

Publication Date

June 2010

Volume

29

Issue

6

Start / End Page

917 / 922

Location

England

Related Subject Headings

  • United States
  • Ultrasonography, Prenatal
  • Risk Factors
  • Prevalence
  • Pregnancy, Multiple
  • Pregnancy Outcome
  • Pregnancy
  • Nuclear Medicine & Medical Imaging
  • Humans
  • Heart Defects, Congenital