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Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans.

Publication ,  Journal Article
Sampson, JH; Brady, M; Raghavan, R; Mehta, AI; Friedman, AH; Reardon, DA; Petry, NA; Barboriak, DP; Wong, TZ; Zalutsky, MR; Lally-Goss, D; Bigner, DD
Published in: Neurosurgery
September 2011

BACKGROUND: Convection-enhanced delivery (CED) permits site-specific therapeutic drug delivery within interstitial spaces at increased dosages through circumvention of the blood-brain barrier. CED is currently limited by suboptimal methodologies for monitoring the delivery of therapeutic agents that would permit technical optimization and enhanced therapeutic efficacy. OBJECTIVE: To determine whether a readily available small-molecule MRI contrast agent, gadolinium-diethylene triamine pentaacetic acid (Gd-DTPA), could effectively track the distribution of larger therapeutic agents. METHODS: Gd-DTPA was coinfused with the larger molecular tracer, I-labeled human serum albumin (I-HSA), during CED of an EGFRvIII-specific immunotoxin as part of treatment for a patient with glioblastoma. RESULTS: Infusion of both tracers was safe in this patient. Analysis of both Gd-DTPA and I-HSA during and after infusion revealed a high degree of anatomical and volumetric overlap. CONCLUSION: Gd-DTPA may be able to accurately demonstrate the anatomic and volumetric distribution of large molecules used for antitumor therapy with high resolution and in combination with fluid-attenuated inversion recovery (FLAIR) imaging, and provide additional information about leaks into cerebrospinal fluid spaces and resection cavities. Similar studies should be performed in additional patients to validate our findings and help refine the methodologies we used.

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Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

September 2011

Volume

69

Issue

3

Start / End Page

668 / 676

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Serum Albumin, Radio-Iodinated
  • Positron-Emission Tomography
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Gadolinium DTPA
 

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Sampson, J. H., Brady, M., Raghavan, R., Mehta, A. I., Friedman, A. H., Reardon, D. A., … Bigner, D. D. (2011). Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans. Neurosurgery, 69(3), 668–676. https://doi.org/10.1227/NEU.0b013e3182181ba8
Sampson, John H., Martin Brady, Raghu Raghavan, Ankit I. Mehta, Allan H. Friedman, David A. Reardon, Neil A. Petry, et al. “Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans.Neurosurgery 69, no. 3 (September 2011): 668–76. https://doi.org/10.1227/NEU.0b013e3182181ba8.
Sampson JH, Brady M, Raghavan R, Mehta AI, Friedman AH, Reardon DA, et al. Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans. Neurosurgery. 2011 Sep;69(3):668–76.
Sampson, John H., et al. “Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans.Neurosurgery, vol. 69, no. 3, Sept. 2011, pp. 668–76. Pubmed, doi:10.1227/NEU.0b013e3182181ba8.
Sampson JH, Brady M, Raghavan R, Mehta AI, Friedman AH, Reardon DA, Petry NA, Barboriak DP, Wong TZ, Zalutsky MR, Lally-Goss D, Bigner DD. Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans. Neurosurgery. 2011 Sep;69(3):668–676.
Journal cover image

Published In

Neurosurgery

DOI

EISSN

1524-4040

Publication Date

September 2011

Volume

69

Issue

3

Start / End Page

668 / 676

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Serum Albumin, Radio-Iodinated
  • Positron-Emission Tomography
  • Neurology & Neurosurgery
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Image Processing, Computer-Assisted
  • Humans
  • Gadolinium DTPA