Glaucoma, Alzheimer disease and other dementia: a longitudinal analysis.

Journal Article (Journal Article)

PURPOSE: To evaluate the risk of developing Alzheimer disease (AD) or other dementia in patients diagnosed with open-angle glaucoma (OAG) in a nationally representative longitudinal sample of elderly persons. METHODS: This retrospective cohort study (January 1, 1994-December 31, 2007) used Medicare 5% claims data. We identified beneficiaries aged 68+ years who had at least two claims with diagnoses of OAG and no Alzheimer or other dementia in 1994, using a 3-year look-back period between 1991 and 1993 (n = 63,235) and beneficiaries matched on age, sex, race, and Charlson index without a diagnosis of OAG throughout the observational period (n = 63,235), using propensity score matching. Using a Cox Proportional Hazards model, we analyzed time to AD diagnosis and time to AD or other dementia diagnosis. RESULTS: Elderly individuals diagnosed with OAG did not have an increased rate of AD and other dementia diagnosis compared to those without OAG during a 14-year follow-up period, even after controlling for relevant covariates present at baseline. CONCLUSIONS: Individuals aged 68+ years diagnosed with OAG have a decreased rate of AD or other dementia diagnosis compared to control patients without an OAG diagnosis. Although OAG and AD are both age-related neurodegenerative diseases, our findings do not support a positive association.

Full Text

Duke Authors

Cited Authors

  • Ou, Y; Grossman, DS; Lee, PP; Sloan, FA

Published Date

  • October 2012

Published In

Volume / Issue

  • 19 / 5

Start / End Page

  • 285 - 292

PubMed ID

  • 22978529

Pubmed Central ID

  • PMC3523354

Electronic International Standard Serial Number (EISSN)

  • 1744-5086

Digital Object Identifier (DOI)

  • 10.3109/09286586.2011.649228


  • eng

Conference Location

  • England