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Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury.

Publication ,  Journal Article
Yoo, PB; Klein, SM; Grafstein, NH; Horvath, EE; Amundsen, CL; Webster, GD; Grill, WM
Published in: Neurourol Urodyn
2007

AIMS: Although electrical stimulation of the pudendal nerve has been shown to evoke reflex micturition-like bladder contractions in both intact and spinalized cats, there is little evidence to suggest that an analogous excitatory reflex exists in humans, particularly those with spinal cord injury (SCI). We present two cases where electrical activation of pudendal nerve afferents was used to evoke excitatory bladder responses. SUBJECTS AND METHODS: A percutaneously placed catheter electrode was used to electrically stimulate the pudendal nerve trunk in two males with SCI. The response was quantified with recorded changes in detrusor pressure and EMG activity of the external anal sphincter. RESULTS: In both individuals, frequency specific (f = 20-50 Hz) activation of the pudendal nerve trunk evoked excitatory bladder contractions that also depended on the stimulus amplitude and bladder volume. CONCLUSION: The results suggest that selective activation of the perineal branches of the pudendal nerve may further augment the excitatory reflex evoked by electrical stimulation.

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Published In

Neurourol Urodyn

DOI

ISSN

0733-2467

Publication Date

2007

Volume

26

Issue

7

Start / End Page

1020 / 1023

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urination
  • Urinary Bladder
  • Spinal Cord Injuries
  • Reflex
  • Neurons, Afferent
  • Muscle, Smooth
  • Muscle Contraction
  • Middle Aged
  • Male
 

Citation

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Yoo, P. B., Klein, S. M., Grafstein, N. H., Horvath, E. E., Amundsen, C. L., Webster, G. D., & Grill, W. M. (2007). Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury. Neurourol Urodyn, 26(7), 1020–1023. https://doi.org/10.1002/nau.20441
Yoo, Paul B., Stephen M. Klein, Neil H. Grafstein, Eric E. Horvath, Cindy L. Amundsen, George D. Webster, and Warren M. Grill. “Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury.Neurourol Urodyn 26, no. 7 (2007): 1020–23. https://doi.org/10.1002/nau.20441.
Yoo PB, Klein SM, Grafstein NH, Horvath EE, Amundsen CL, Webster GD, et al. Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury. Neurourol Urodyn. 2007;26(7):1020–3.
Yoo, Paul B., et al. “Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury.Neurourol Urodyn, vol. 26, no. 7, 2007, pp. 1020–23. Pubmed, doi:10.1002/nau.20441.
Yoo PB, Klein SM, Grafstein NH, Horvath EE, Amundsen CL, Webster GD, Grill WM. Pudendal nerve stimulation evokes reflex bladder contractions in persons with chronic spinal cord injury. Neurourol Urodyn. 2007;26(7):1020–1023.
Journal cover image

Published In

Neurourol Urodyn

DOI

ISSN

0733-2467

Publication Date

2007

Volume

26

Issue

7

Start / End Page

1020 / 1023

Location

United States

Related Subject Headings

  • Urology & Nephrology
  • Urination
  • Urinary Bladder
  • Spinal Cord Injuries
  • Reflex
  • Neurons, Afferent
  • Muscle, Smooth
  • Muscle Contraction
  • Middle Aged
  • Male