Dorsal genital nerve stimulation for the treatment of overactive bladder symptoms.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

AIM: To evaluate percutaneous placement of electrodes adjacent to the dorsal genital nerve (DGN) and measure the effects of electrical stimulation on symptoms of urge incontinence during 1 week of home use. METHODS: Prospective, multicenter study. Subjects with urge incontinence underwent percutaneous placement of an electrode using local anesthetic. Test stimulation was applied to confirm electrode placement and cystometry was conducted with and without application of electrical stimulation. A 7-day testing period with the electrode connected to an external pulse generator was performed and was followed by a 3-day post-treatment test period. Bladder diaries, 24 hr pad tests, and adverse event queries were obtained. RESULTS: Twenty-one women were enrolled with an average age of 52.7 years and average duration of incontinence of 6 years. Percutaneous electrode placement required 5-10 min and was well tolerated. There was no relationship between the acute effects of stimulation on cystometry and the results during home use. Pad weight was reduced by >or= 50% in 13 of 17 subjects (76%) (4 did not complete 24 hr pad testing) and 47% of subjects reported >or=50% reduction in incontinence episodes. Of the subjects who reported severe urgency at baseline, 81% experienced a 50% or greater improvement. Seven subjects experienced nine adverse events ranging from skin irritation to pain and bruising around the electrode exit site. CONCLUSIONS: Electrodes to stimulate the DGN can be placed percutaneously and a home testing period showed a reduction in overactive bladder symptoms with DGN stimulation.

Full Text

Duke Authors

Cited Authors

  • Goldman, HB; Amundsen, CL; Mangel, J; Grill, J; Bennett, M; Gustafson, KJ; Grill, WM

Published Date

  • 2008

Published In

Volume / Issue

  • 27 / 6

Start / End Page

  • 499 - 503

PubMed ID

  • 18092334

Pubmed Central ID

  • PMC3646571

Electronic International Standard Serial Number (EISSN)

  • 1520-6777

Digital Object Identifier (DOI)

  • 10.1002/nau.20544


  • eng

Conference Location

  • United States