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Cadmium-induced neoplastic transformation of human prostate epithelial cells.

Publication ,  Journal Article
Nakamura, K; Yasunaga, Y; Ko, D; Xu, LL; Moul, JW; Peehl, DM; Srivastava, S; Rhim, JS
Published in: Int J Oncol
March 2002

Cadmium is a ubiquitous environmental human carcinogen. Epidemiological and animal studies have suggested its carcinogenic potential on the prostate. In the present study, non-tumorigenic human prostate epithelial cells (pRNS-1-1) immortalized by simian papovavirus (SV40) were transformed after repeated exposures to cadmium. Such transformants showed morphological alterations, anchorage-independent growth in soft agar, and formed tumors when transplanted into SCID mice. The tumors were characterized histologically as poorly-differentiated adenocarcinomas, expressing prostate-specific antigen (PSA), androgen receptor (AR), prostate stem cell antigen (PSCA), NKX3.1 and cytokeratin 8 (CK8). These findings provide evidence of malignant transformation of human prostate epithelial cells exposed to this environmentally important chemical.

Duke Scholars

Published In

Int J Oncol

ISSN

1019-6439

Publication Date

March 2002

Volume

20

Issue

3

Start / End Page

543 / 547

Location

Greece

Related Subject Headings

  • Tumor Cells, Cultured
  • Time Factors
  • Simian virus 40
  • Reverse Transcriptase Polymerase Chain Reaction
  • Receptors, Androgen
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Oncology & Carcinogenesis
  • Mice, SCID
  • Mice
 

Citation

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ICMJE
MLA
NLM
Nakamura, K., Yasunaga, Y., Ko, D., Xu, L. L., Moul, J. W., Peehl, D. M., … Rhim, J. S. (2002). Cadmium-induced neoplastic transformation of human prostate epithelial cells. Int J Oncol, 20(3), 543–547.
Nakamura, Keiichiro, Yutaka Yasunaga, Daejin Ko, Linda L. Xu, Judd W. Moul, Donna M. Peehl, Shiv Srivastava, and Johng S. Rhim. “Cadmium-induced neoplastic transformation of human prostate epithelial cells.Int J Oncol 20, no. 3 (March 2002): 543–47.
Nakamura K, Yasunaga Y, Ko D, Xu LL, Moul JW, Peehl DM, et al. Cadmium-induced neoplastic transformation of human prostate epithelial cells. Int J Oncol. 2002 Mar;20(3):543–7.
Nakamura, Keiichiro, et al. “Cadmium-induced neoplastic transformation of human prostate epithelial cells.Int J Oncol, vol. 20, no. 3, Mar. 2002, pp. 543–47.
Nakamura K, Yasunaga Y, Ko D, Xu LL, Moul JW, Peehl DM, Srivastava S, Rhim JS. Cadmium-induced neoplastic transformation of human prostate epithelial cells. Int J Oncol. 2002 Mar;20(3):543–547.

Published In

Int J Oncol

ISSN

1019-6439

Publication Date

March 2002

Volume

20

Issue

3

Start / End Page

543 / 547

Location

Greece

Related Subject Headings

  • Tumor Cells, Cultured
  • Time Factors
  • Simian virus 40
  • Reverse Transcriptase Polymerase Chain Reaction
  • Receptors, Androgen
  • Prostatic Neoplasms
  • Prostate-Specific Antigen
  • Oncology & Carcinogenesis
  • Mice, SCID
  • Mice