Cadmium-induced neoplastic transformation of human prostate epithelial cells.

Journal Article (Journal Article)

Cadmium is a ubiquitous environmental human carcinogen. Epidemiological and animal studies have suggested its carcinogenic potential on the prostate. In the present study, non-tumorigenic human prostate epithelial cells (pRNS-1-1) immortalized by simian papovavirus (SV40) were transformed after repeated exposures to cadmium. Such transformants showed morphological alterations, anchorage-independent growth in soft agar, and formed tumors when transplanted into SCID mice. The tumors were characterized histologically as poorly-differentiated adenocarcinomas, expressing prostate-specific antigen (PSA), androgen receptor (AR), prostate stem cell antigen (PSCA), NKX3.1 and cytokeratin 8 (CK8). These findings provide evidence of malignant transformation of human prostate epithelial cells exposed to this environmentally important chemical.

Full Text

Duke Authors

Cited Authors

  • Nakamura, K; Yasunaga, Y; Ko, D; Xu, LL; Moul, JW; Peehl, DM; Srivastava, S; Rhim, JS

Published Date

  • March 2002

Published In

Volume / Issue

  • 20 / 3

Start / End Page

  • 543 - 547

PubMed ID

  • 11836566

International Standard Serial Number (ISSN)

  • 1019-6439


  • eng

Conference Location

  • Greece