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Lateral biopsies added to the traditional sextant prostate biopsy pattern increases the detection rate of prostate cancer.

Publication ,  Journal Article
Bauer, JJ; Zeng, J; Zhang, W; McLeod, DG; Sesterhenn, IA; Connelly, RR; Mun, SK; Moul, JW
Published in: Prostate Cancer Prostatic Dis
July 2000

Urologists routinely use the systematic sextant needle biopsy technique to detect prostate cancer. However, recent evidence suggests that this technique has a significant sampling error and data based upon whole-mounted step-sectioned radical prostatectomy specimens using a three-dimensional computer-assisted prostate biopsy simulator suggests that an increased detection rate is possible using laterally placed biopsies. The simulated 10-core biopsy pattern (traditional sextant biopsy cores and four laterally placed biopsies in the right and left apex and mid portion of the prostate gland) was shown to be superior to the traditional sextant biopsy. The objective of this pilot study was to confirm the higher prostate cancer detection rate obtained using the 10-core biopsy pattern in patients. We reviewed data on 35 consecutive patients with a pathologic diagnosis of prostate cancer biopsied by a single urologist using the 10-core biopsy pattern. The frequency of positive biopsy was determined for each core. Additionally, the sextant and 10-core prostate biopsy patterns were compared with respect to prostate cancer detection rate. Of the 35 patients diagnosed with prostate cancer, 54.3%(19/35) were diagnosed by the sextant biopsy only. The 10-core pattern resulted in an additional 45.7%(16/35) of patients being diagnosed solely with the laterally placed biopsies. The laterally placed biopsies had the highest frequency of positive biopsies when compared to the sextant cores. In conclusion, biopsy protocols that use laterally placed biopsies based upon a five region anatomical model are superior to the routinely used sextant prostate biopsy pattern. Prostate Cancer and Prostatic Diseases (2000) 3, 43-46

Duke Scholars

Published In

Prostate Cancer Prostatic Dis

DOI

EISSN

1476-5608

Publication Date

July 2000

Volume

3

Issue

1

Start / End Page

43 / 46

Location

England

Related Subject Headings

  • Urology & Nephrology
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis
 

Citation

APA
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Bauer, J. J., Zeng, J., Zhang, W., McLeod, D. G., Sesterhenn, I. A., Connelly, R. R., … Moul, J. W. (2000). Lateral biopsies added to the traditional sextant prostate biopsy pattern increases the detection rate of prostate cancer. Prostate Cancer Prostatic Dis, 3(1), 43–46. https://doi.org/10.1038/sj.pcan.4500397
Bauer, J. J., J. Zeng, W. Zhang, D. G. McLeod, I. A. Sesterhenn, R. R. Connelly, S. K. Mun, and J. W. Moul. “Lateral biopsies added to the traditional sextant prostate biopsy pattern increases the detection rate of prostate cancer.Prostate Cancer Prostatic Dis 3, no. 1 (July 2000): 43–46. https://doi.org/10.1038/sj.pcan.4500397.
Bauer JJ, Zeng J, Zhang W, McLeod DG, Sesterhenn IA, Connelly RR, et al. Lateral biopsies added to the traditional sextant prostate biopsy pattern increases the detection rate of prostate cancer. Prostate Cancer Prostatic Dis. 2000 Jul;3(1):43–6.
Bauer, J. J., et al. “Lateral biopsies added to the traditional sextant prostate biopsy pattern increases the detection rate of prostate cancer.Prostate Cancer Prostatic Dis, vol. 3, no. 1, July 2000, pp. 43–46. Pubmed, doi:10.1038/sj.pcan.4500397.
Bauer JJ, Zeng J, Zhang W, McLeod DG, Sesterhenn IA, Connelly RR, Mun SK, Moul JW. Lateral biopsies added to the traditional sextant prostate biopsy pattern increases the detection rate of prostate cancer. Prostate Cancer Prostatic Dis. 2000 Jul;3(1):43–46.

Published In

Prostate Cancer Prostatic Dis

DOI

EISSN

1476-5608

Publication Date

July 2000

Volume

3

Issue

1

Start / End Page

43 / 46

Location

England

Related Subject Headings

  • Urology & Nephrology
  • 3211 Oncology and carcinogenesis
  • 3202 Clinical sciences
  • 1112 Oncology and Carcinogenesis